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Preparation method and application of polydatin phospholipid complex granule

The technology of Polygoniside phospholipid and compound is applied in the field of antibacterial of livestock and poultry, which can solve the problems of poor bioavailability treatment effect, etc., and achieve the effects of improving the antioxidant capacity of drugs, enhancing drug targeting, and increasing drug absorption.

Inactive Publication Date: 2017-01-25
SHANDONG ENKANG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, combining polydatin with phospholipid complexes to develop a polydatin phospholipid complex can overcome the problems of poor water solubility and low bioavailability of polydatin in poultry to the greatest extent, and become an urgent need. solved problem

Method used

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  • Preparation method and application of polydatin phospholipid complex granule
  • Preparation method and application of polydatin phospholipid complex granule
  • Preparation method and application of polydatin phospholipid complex granule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A preparation method of polydatin phospholipid complex granules, comprising the following steps:

[0042] (1) Mix polydatin and soybean lecithin in a mass ratio of 1:1, then add it to ethanol, the concentration of polydatin is 40g L -1, reacted at 60°C for 5 hours, removed the solvent, rinsed with cold acetone at 4°C, drained, and dried in vacuum at 60°C and -0.09Mpa for 8 minutes to obtain polydatin phospholipid complex;

[0043] Described polydatin is prepared as follows:

[0044] After crushing the root and stem of Polygonum cuspidatum to a particle size of 2-3 mm, mix it with a 70% ethanol solution at a ratio of 1:8 to a solid-liquid ratio, soak for 2 hours, and extract it by microwave treatment at a temperature of 51°C and a strength of 650W. 100s, extract twice, combine the extracts, concentrate under reduced pressure to remove the solvent, add twice the volume of water, extract 6 times with ether, remove anthraquinone impurities, centrifuge, take the supernatant...

Embodiment 2

[0047] A preparation method of polydatin phospholipid complex granules, comprising the following steps:

[0048] (1) Mix polydatin and soybean lecithin in a mass ratio of 2:1, then add it to ethanol, the concentration of polydatin is 30g L -1 , reacted at 40°C for 4 hours, removed the solvent, rinsed with cold acetone at 4°C, drained, and dried in vacuum at 60°C and -0.09Mpa for 8 minutes to obtain polydatin phospholipid complex;

[0049] Described polydatin is prepared as follows:

[0050] Crush the roots and stems of Polygonum cuspidatum to a particle size of 2-3 mm, then mix it with a 70% ethanol solution at a ratio of 1:8 to a solid-liquid ratio, soak for 2 hours, and extract it by microwave treatment for 100 seconds at a temperature of 51°C and a strength of 650W. , extracted twice, combined the extracts, concentrated under reduced pressure to remove the solvent, added twice the volume of water, extracted 6 times with ether, removed anthraquinone impurities, centrifuged,...

Embodiment 3

[0053] The preparation method of polydatin phospholipid complex granules as described in Example 1, the difference is:

[0054] Mix polydatin and soybean lecithin in a mass ratio of 3:1, then add it to ethanol, the concentration of polydatin is 20g L -1 , reacted at 51°C for 3 hours, removed the solvent, rinsed with cold acetone at 4°C, drained, and dried in vacuum at 60°C and -0.09Mpa for 8 minutes to obtain polydatin phospholipid complex;

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Abstract

The invention relates to a preparation method and application of a polydatin phospholipid complex granule. The preparation method comprises the following steps: firstly, mixing polydatin with soybean phosphatide, then adding into solvent, and reacting to obtain a polydatin phospholipid complex; secondly, mixing the polydatin phospholipid complex with glucose, drying and granulating to obtain the polydatin phospholipid complex granule. According to the polydatin phospholipid complex granule prepared by the preparation method disclosed by the invention, poultry bacterial diseases can be effectively prevented; a medicine and phospholipid form a molecular complex, so that the activity of the medicine is enhanced, side reaction of the medicine is reduced, the oxidation resistance of the medicine is improved, the medicine targeting property is improved, the pharmacological function is prolonged, the medicine absorption is enhanced, viscous components are enabled to sufficiently realize the potency, and further the bioavailability of the medicine is further improved. Therefore, the polydatin phospholipid complex granule has great application value in preventing and controlling the poultry bacterial diseases.

Description

technical field [0001] The present invention relates to a preparation method and application of polydatin phospholipid complex granules, in particular to a method for preparing polydatin and phospholipid complex granules and the application of the granules in treating bacterial diseases of livestock and poultry The invention belongs to the field of livestock and poultry antibacterial technology. Background technique [0002] With the development of China's economy and the rapid growth of animal husbandry, animal diseases not only cause huge economic losses to animal husbandry production, but also some zoonotic diseases directly threaten the survival and development of human beings. Bacterial diseases are a class of infectious diseases that seriously endanger the chicken industry, such as chicken cholera, pullorum, colibacillosis, staphylococcal disease, etc., which have brought serious economic losses to the chicken industry. Due to the influence of factors such as disease ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/54A61K31/7034A61P31/04
CPCA61K9/1617A61K31/7034
Inventor 陈抗付荣强时建蓬李刚张含侠段淑霞张玉霞孙明珠张新菊马文浩
Owner SHANDONG ENKANG PHARMA
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