Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation and application of ZIF-8@zinc phthalocyanine composite

A composite material, the technology of ZIF-8, is applied in the directions of medical preparations without active ingredients, medical preparations containing active ingredients, and materials treated by wave energy or particle radiation, which can solve the problem of loss of photodynamic activity, phthalocyanine photodynamic Reduce the activity and other problems, to achieve the effect of superior photodynamic activity, uniform morphology, and broaden the scope of application

Active Publication Date: 2017-02-01
FUZHOU UNIV
View PDF1 Cites 20 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The most important impact is that aggregation provides a very effective non-radiative energy consumption method, so that the energy absorbed by phthalocyanine after irradiation is mainly used for its own depolymerization, and cannot effectively generate excited triplet states and then produce 1 o 2 , so that the photodynamic activity of phthalocyanine is greatly reduced, and even the photodynamic activity is lost in severe cases.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation and application of ZIF-8@zinc phthalocyanine composite
  • Preparation and application of ZIF-8@zinc phthalocyanine composite
  • Preparation and application of ZIF-8@zinc phthalocyanine composite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A preparation method of ZIF-8@phthalocyanine zinc composite material, the specific steps are:

[0033] 1) Preparation of ZIF-8@Zinc Phthalocyanine Composite Material: Weigh 150mg Zn(NO 3 ) 2 ·(H 2 O) 6 , dissolved in 7.5mL of methanol, 330mg of 2-methylimidazole was dissolved in 7.5mL of methanol, 10mg of zinc phthalocyanine (zinc phthalocyanine composite material) was dissolved in 1mL of N,N dimethylformamide, fully ultrasonicated Dissolve completely;

[0034] 2) Pour the above three fully dissolved solutions into a jar, then add 4mg of surfactant CTAB, and stir for 0.5h in one pot at room temperature;

[0035] 3) After the reaction is complete, collect the crude product by centrifugation at a centrifugation speed of 7000 rpm / min for 10 min; wash and purify the crude product with methanol, 15 mL each time, and wash three times;

[0036] 4) The obtained product was vacuum-dried in an oven at 60°C for 2 hours, and ground in an agate mortar to obtain the final produc...

Embodiment 2

[0038] A preparation method of ZIF-8@phthalocyanine zinc composite material, the specific steps are:

[0039] 1) Preparation of ZIF-8@Zinc Phthalocyanine Composite Material: Weigh 150mg Zn(NO 3 ) 2 ·(H 2 O) 6 , dissolved in 7.5mL of methanol, 330mg of 2-methylimidazole was dissolved in 7.5mL of methanol, 10mg of zinc phthalocyanine (zinc phthalocyanine composite material) was dissolved in 1mL of N,N dimethylformamide, fully ultrasonicated Dissolve completely;

[0040] 2) Pour the above three fully dissolved solutions into a jar, then add 4mg of surfactant CTAB, and stir for 0.25h in one pot at room temperature;

[0041] 3) After the reaction is complete, collect the crude product by centrifugation at a speed of 6000rpm / min for 15 minutes; wash and purify the crude product with methanol, 15 mL each time, and wash three times;

[0042] 4) The obtained product was vacuum-dried in an oven at 40°C for 3.5 hours, and ground in an agate mortar to obtain the final product.

Embodiment 3

[0044] A preparation method of ZIF-8@phthalocyanine zinc composite material, the specific steps are:

[0045] 1) Preparation of ZIF-8@Zinc Phthalocyanine Composite Material: Weigh 150mg Zn(NO 3 ) 2 ·(H 2 O) 6 , dissolved in 7.5mL of methanol, 330mg of 2-methylimidazole was dissolved in 7.5mL of methanol, 10mg of zinc phthalocyanine (zinc phthalocyanine composite material) was dissolved in 1mL of N,N dimethylformamide, fully ultrasonicated Dissolve completely;

[0046] 2) Pour the above three fully dissolved solutions into a jar, then add 4 mg of surfactant CTAB, and stir for 1 hour at room temperature;

[0047] 3) After the reaction is complete, collect the crude product by centrifugation at a centrifugation speed of 10,000 rpm / min for 8 min; wash and purify the crude product with methanol, 15 mL each time, and wash three times;

[0048] 4) The obtained product was vacuum-dried in an oven at 70°C for 2.5 hours, and ground in an agate mortar to obtain the final product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses preparation and application of a ZIF-8@zinc phthalocyanine composite. According to a preparation method for the ZIF-8@zinc phthalocyanine composite, the composite is synthesized by using a one-pot method at room temperature with Zn(NO3)2.(H2O)6 as a metal source, 2-methylimidazole as a ligand, CTAB as a surfactant and zinc phthalocyanine as a photosensitizer. The prepared ZIF-8@zinc phthalocyanine composite has the advantages of uniform particle distribution, good crystallization degree and good photodynamic activity. The preparation method has the advantages of simple operation, high yield, good product stability and the like, has wide application prospect and broadens the application scope of ZIF materials.

Description

technical field [0001] The invention belongs to the field of metal organic framework materials used as drug transport, and specifically relates to the preparation of a metal organic framework material ZIF-8@phthalocyanine zinc composite material and its application in photodynamic therapy. Background technique [0002] Metal-organic frameworks (Metal Organic Frameworks, referred to as MOFs) are a type of organic-inorganic hybrid materials, also known as coordination polymers (coordination polymers), which are composed of bridged multi-dentate organic ligands (mainly aromatic polyacids) and polyalkali) and metal centers (metal ions or metal oxygen clusters) through coordination self-assembly to form a porous material with a periodic network structure. Due to the special composition of MOFs, its properties are different from both inorganic porous materials and general organic complexes. It has both the flexibility of organic materials and the rigidity of inorganic materials. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K41/00A61K47/69A61P35/00
CPCA61K41/0076
Inventor 薛金萍年夫宇叶焕年
Owner FUZHOU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com