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Biological protein glue-triamcinolone acetonide slow release agent as well as preparation method and application of slow release agent

A technology of biological protein glue and biological protein, which is applied in the field of bioprotein glue-triamcinolone acetonide sustained-release agent and its preparation, can solve the problems of puncture bleeding, increase patient pain and economic burden, and different curative effects, and achieve the goal of prolonging the dissolution time Effect

Inactive Publication Date: 2017-02-15
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the injection of local steroid drugs often requires multiple administrations with the assistance of interventional equipment, which will undoubtedly increase the pain and financial burden of patients. Different surgical wounds, injection methods and injection doses will also bring different curative effects , at the same time, there is a risk of puncture bleeding after multiple injections

Method used

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  • Biological protein glue-triamcinolone acetonide slow release agent as well as preparation method and application of slow release agent
  • Biological protein glue-triamcinolone acetonide slow release agent as well as preparation method and application of slow release agent
  • Biological protein glue-triamcinolone acetonide slow release agent as well as preparation method and application of slow release agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1: Preparation of bioprotein glue-triamcinolone acetonide sustained-release agent

[0035] 1) Configure aprotinin solution

[0036] Take 100 mg of aprotinin, dissolve it with 900 μl of normal saline in a sterile, enzyme-free environment, and mix well to obtain an aprotinin solution;

[0037] 2) Configure the main body glue solution of biological protein

[0038] According to the instruction manual of the purchased medical biological protein glue, dissolve the main glue with the supporting main glue solution to obtain the biological protein main glue solution;

[0039] 3) Configure the catalyst solution

[0040] According to the instruction manual of the purchased medical biological protein glue, dissolve the catalyst (thrombin) with the supporting calcium chloride solution to obtain the catalyst (thrombin) solution;

[0041] 4) Take the matching first syringe, extract 1ml of the biological protein main glue solution prepared in step 2), 10 μl of the aprotinin...

Embodiment 2

[0042] Example 2: Preparation of bioprotein glue-triamcinolone acetonide sustained-release agent

[0043] 1) Configure aprotinin solution

[0044] Take 100 mg of aprotinin, dissolve it with 900 μl of normal saline in a sterile, enzyme-free environment, and mix well to obtain an aprotinin solution;

[0045]2) Configure the main body glue solution of biological protein

[0046] According to the instruction manual of the purchased medical biological protein glue, dissolve the main glue with the supporting main glue solution to obtain the biological protein main glue solution;

[0047] 3) Configure the catalyst solution

[0048] According to the instruction manual of the purchased medical biological protein glue, dissolve the catalyst (thrombin) with the supporting calcium chloride solution to obtain the catalyst (thrombin) solution;

[0049] 4) Take the matching first syringe, extract 1ml of the biological protein main glue solution prepared in step 2), 10 μl of the aprotinin ...

Embodiment 3

[0050] Example 3: Preparation of bioprotein glue-triamcinolone acetonide sustained-release agent

[0051] 1) Configure aprotinin solution

[0052] Take 100 mg of aprotinin, dissolve it with 900 μl of normal saline in a sterile, enzyme-free environment, and mix well to obtain an aprotinin solution;

[0053] 2) Configure the main body glue solution of biological protein

[0054] According to the instruction manual of the purchased medical biological protein glue, dissolve the main glue with the supporting main glue solution to obtain the biological protein main glue solution;

[0055] 3) Configure the catalyst solution

[0056] According to the instruction manual of the purchased medical biological protein glue, dissolve the catalyst (thrombin) with the supporting calcium chloride solution to obtain the catalyst (thrombin) solution;

[0057] 4) Take the matching first syringe, extract 1ml of the biological protein main glue solution prepared in step 2), 10 μl of the aprotinin...

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Abstract

The invention provides a biological protein glue-triamcinolone acetonide slow release agent as well as a preparation method and application of the slow release agent. The slow release agent comprises biological protein glue, aprotinin and triamcinolone acetonide, wherein the biological protein glue is used as a medicine carrier, the aprotinin is used as a slow solvent, and triamcinolone acetonide is taken as an effective medicine component. The prepared biological protein glue-triamcinolone acetonide slow release agent is directly sprayed to a corresponding surgical region of a digestive tract by virtue of an endoscope and is capable of playing a durable anti-inflammatory role, so that the formation of postoperative scars is reduced, the postoperative esophageal stenosis is prevented, and the life quality of a patient is effectively improved.

Description

technical field [0001] The invention relates to the field of sustained-release preparations, in particular to bioprotein glue-triamcinolone acetonide sustained-release preparations, preparation methods and applications. Background technique [0002] Esophageal cancer is a malignant tumor originating from the epithelium of the esophageal mucosa. The incidence of esophageal cancer ranks eighth among malignant tumors worldwide, and its mortality rate ranks sixth. my country is one of the countries with the highest incidence of esophageal cancer. In China, there are more than 220,000 new cases of esophageal cancer each year, and about 200,000 deaths. Usually, patients with esophageal cancer have progressed to the middle and late stages when they are diagnosed, and the overall 5-year survival rate is less than 20%. Early esophageal cancer can usually be cured by endoscopic minimally invasive treatment, and the 5-year survival rate can exceed 95%. At present, endoscopic mucosal re...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/58A61K47/42A61P1/00A61P29/00
CPCA61K9/0002A61K9/0053A61K9/7015A61K31/58
Inventor 彭贵勇刘云杰李敏吴宏博陈瑶代剑华
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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