Heterogeneous cell three-dimensional printing system and heterogeneous cell three-dimensional printing method

A cell printing and three-dimensional printing technology, applied in biochemical equipment and methods, biological material sampling methods, biomass post-processing, etc., can solve the problems of inability to complete three-dimensional printing of heterogeneous cells, and achieve the effect of efficient construction
CN106399078AActive Publication Date: 2017-02-15TSINGHUA UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TSINGHUA UNIV
Publication Date
2017-02-15

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Abstract

The present invention relates to a heterogeneous cell three-dimensional printing system, which comprises a moving platform, an extruded cell printing mechanism fixed on the moving platform, a dropping-off type cell printing mechanism fixed on the moving platform, an observation unit for observing and feeding back the cell printing condition, and a control unit, wherein the control unit controls the extruded cell printing mechanism to complete the three-dimensional cell hydrogel structure printing, and then controls the dropping-off type cell printing mechanism to complete the printing of single or multiple cells on the three-dimensional cell hydrogel structure. According to the present invention, the micro-extrusion type printing technology and the dropping-off type cell printing technology based on the alternating hysteresis force driving are integrated, such that the efficient construction of the macroscopical cell clusters is ensured, the construction of the microenvironment of the microcosmic single cell near the cluster cells is ensured, the in vitro heterogeneous cell model construction method integrating the efficiency and the precision is created, and the system and the method have important pathology and pharmacology application potential.
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Description

technical field

[0001] The invention belongs to the fields of biomanufacturing and cell printing, and in particular relates to a precise and controlled assembly device and process for heterogeneous cells. Background technique

[0002] In recent years, cell printing technology has played an increasingly important role in the fields of tissue engineering, pathological model construction, drug screening and detection, and cell behavior research. In the field of tissue engineering, cell printing technology realizes the three-dimensional controlled assembly of heterogeneous cells, and can construct complex tissue structures in vitro, which promotes the development of tissue engineering in the direction of scale, automation, and computer-aided processing; in pathological models In the field of construction, cell printing can assemble diseased cells (such as tumor cells) and normal cells in a specific order, which provides an effective research method for medical workers to study t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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