Drug composition of amoxicillin potassium clavulanate and application thereof

A technology of potassium clavulanate and amoxicillin, which is applied in the field of medicine, can solve the problems of short action time, large side effects, high price and the like, and achieves good inhibitory effect and inhibitory increase effect.

Active Publication Date: 2017-03-08
XIANGBEI WELMAN PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the drugs for the clinical treatment of asthma are mainly corticosteroids, bronchodilators, leukotriene inhibitors, etc., but there are disadvantages such as high price, large side effects, and short duration of action.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: Pharmaceutical Composition (Amoxicillin and Clavulanate Potassium Tablets 7:1)

[0034] Prescription: amoxicillin trihydrate 1004.3g, potassium clavulanate 149.5g, microcrystalline cellulose 149.6g, silicon dioxide 25.2g, sodium carboxymethyl starch 30.3g and magnesium stearate 3.5g.

[0035] Preparation method: Take amoxicillin trihydrate, potassium clavulanate, silicon dioxide and sodium carboxymethyl starch, mix them evenly, press them into blocks, and crush them into granules. Mix the granules with microcrystalline cellulose and magnesium stearate evenly, and compress into tablets to make 1000 tablets.

Embodiment 2

[0036] Example 2: Pharmaceutical Composition (Amoxicillin and Clavulanate Potassium Tablets 2:1)

[0037] Prescription: 459.1 g of amoxicillin trihydrate, 239.3 g of potassium clavulanate, 91.4 g of microcrystalline cellulose, 14.8 g of silicon dioxide, 20.3 g of sodium carboxymethyl starch and 2.0 g of magnesium stearate.

[0038] Preparation method: adopt the same method as in Example 1 to make 1000 pieces.

Embodiment 3

[0039] Example 3: Pharmaceutical Composition (Amoxicillin and Clavulanate Potassium Tablets 10:1)

[0040] Prescription: Amoxicillin trihydrate 1147.8g, potassium clavulanate 119.6g, microcrystalline cellulose 132.7g, silicon dioxide 20.4g, sodium carboxymethyl starch 34.5g and magnesium stearate 4.1g.

[0041] Preparation method: adopt the same method as in Example 1 to make 1000 pieces.

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Abstract

The invention provides a drug composition, wherein the ratio of amoxicillin and potassium clavulanate in the drug composition is 7: 1. The drug composition can significantly lighten the rise of IgE level induced by allergen, and can be used for preventing or treating asthma, in particular to the asthma caused by air pollution such as haze; besides, the drug has good effect for the asthma combined bacterial infection.

Description

technical field [0001] The invention relates to a pharmaceutical composition of amoxicillin and potassium clavulanate and application thereof, belonging to the field of medicine. Background technique [0002] In recent years, with the improvement of the level of industrialization, the problems of environmental degradation and air pollution have become increasingly prominent. A large amount of pollutants and particulate matter are suspended in the air, resulting in a decline in air quality and visibility. Many cities across the country have experienced smog, and some have lasted for more than a week. Among them, particulate matter with a diameter of less than or equal to 2.5 microns is called PM2.5, which is suspended in the atmosphere and can enter the lungs directly through the airway after breathing into the human body. PM2.5 contains toxic and harmful substances such as sulfate and nitrate, and can also carry pathogenic microorganisms such as viruses and bacteria. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/43A61K31/424A61K45/06A61P31/04A61P31/02A61P11/06
CPCA61K31/424A61K31/43A61K45/06A61K2300/00
Inventor 不公告发明人
Owner XIANGBEI WELMAN PHARMA CO LTD
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