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Metronidazole detection method

A detection method and technology for metronidazole are applied in the detection field of detecting metronidazole by using amino-functionalized MCM-41 modified electrodes, and the effects of simple preparation method, high yield and easy operation are achieved.

Inactive Publication Date: 2017-03-08
GUANGXI NORMAL UNIV FOR NATITIES
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Problems solved by technology

At present, the detection method of metronidazole based on amino functionalized MCM-41 modified electrode has not been reported yet.

Method used

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Embodiment Construction

[0031] 31. In order to express the present invention more clearly, the present invention will be further described through specific examples below.

[0032] 32. Preparation of amino functionalized MCM-41

[0033] 33. 1.1 Preparation: take an appropriate amount of MCM-41 and activate it at 130°C for 2 hours, accurately weigh 0.2002g of activated MCM-41 into an 80mL flask, add 50mL of absolute ethanol, control the temperature at 60°C, and add 3- Aminopropyltriethoxysilane 2mL, stirred and refluxed at 1000-1400rpm for 6h, then cooled to room temperature and centrifuged in a centrifuge, the centrifuged solid was washed with distilled water until the filtrate was neutral, and the cleaned solid was placed in Vacuum drying at 80° C. for 6 h gave amino-functionalized MCM-41 as a solid.

[0034] 34. 1.2 Confirmation of amino functionalized MCM-41 product

[0035] 35. Use PE spectrum 65 Fourier transform infrared spectrometer to characterize the synthesized MCM-41 material and amino f...

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Abstract

The invention provides a metronidazole detection method and belongs to the technical field of metronidazole. The method includes: adopting a mode of dropwise smearing amino functionization MCM-41 on a glass carbon electrode to prepare an amino functionalization MCM-41 modified electrode; utilizing a three-electrode system, and adopting a square wave voltammetry to detect metronidazole. A result shows that amino functionalization MCM-41 modified electrode differential pulse voltammetry is adopted to detect metronidazole different in concentration, peak current is constantly increased along with increase of concentration of a metronidazole solution, the peak current of metronidazole presents good linear relation with the concentration of metronidazole, and correlation coefficient is 0.9974. Detection limit of the method is 1.7x10-7mol / L; comparison tests show that the peak current of metronidazole on the amino functionalization MCM-41 modified electrode is obviously higher than those on an MCM-41 modified electrode and a naked glass carbon electrode. The metronidazole detection method has the advantages of high sensitivity, simplicity and convenience in operation, quickness, low instrument cost and easiness in realizing automation.

Description

[0001] 【Technical field】 [0002] 2. The present invention relates to the technical field of metronidazole detection, in particular to a method for detecting metronidazole using an amino functionalized MCM-41 modified electrode. [0003] 3. [0004] 4. [Background Technology] [0005] 5. Metronidazole (Metronidazole, MET), also known as metronidazole, metronidazole, full name metronidazole, chemical name 2-methyl-5-nitroimidazole-1-ethanol, molecular formula It is C6H9N3O3, which is a metronidazole compound, and its structural formula is as follows: [0006] 6. [0007] 7. Metronidazole is a white or slightly yellow crystal or crystalline powder; it has a slight odor, bitter and slightly salty taste, and is an uncharged small molecular compound that can enter microorganisms through diffusion. The nitro group in the molecule is reduced to an amino group under anaerobic conditions to form a highly cytotoxic intermediate with biological activity. This intermediate can interac...

Claims

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Application Information

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IPC IPC(8): G01N27/48
CPCG01N27/48
Inventor 刘宇霞梁彩云彭金云黄淋
Owner GUANGXI NORMAL UNIV FOR NATITIES
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