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A kind of nepetalactone microcapsule, its preparation method and its application in the preparation of mosquito repellent products

A technology of nepetalactone and ester microcapsules, applied in the field of daily chemicals, can solve the problems of application limitation, strong volatility effect of pseudo nepetalactone, short-lived, strong volatility, etc. The effect of high encapsulation rate

Active Publication Date: 2020-01-10
广州睿森生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to its strong volatility, its application is greatly limited
[0004] In order to solve the problem of short-term effect caused by the strong volatility of nepetalactone, so that it can play a long-term mosquito repellent effect, the sustained release dosage form of nepetalactone should be further developed

Method used

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  • A kind of nepetalactone microcapsule, its preparation method and its application in the preparation of mosquito repellent products
  • A kind of nepetalactone microcapsule, its preparation method and its application in the preparation of mosquito repellent products
  • A kind of nepetalactone microcapsule, its preparation method and its application in the preparation of mosquito repellent products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Dissolve 40g of gelatin in 200mL of deionized water, 80g of porous starch in 400mL of deionized water, heat and stir at 70°C until clear and transparent; dissolve 4g of nepetalactone in 50mL of absolute ethanol, preheat, Then the solution was added dropwise into the porous starch solution, and continuously stirred for 1 h, then added into the gelatin solution and continued to stir for 2 h, and finally a coarse emulsion containing nepetalactone microcapsules was obtained. The above emulsion is spray-dried, the conditions are: the feed flow rate is 60ml / min, and the drying air flow rate is 75m 3 / h, the hot air inlet temperature is 200°C, and the outlet temperature is 60°C.

Embodiment 2

[0057] Dissolve 60g of gelatin in 300mL of deionized water, 60g of porous starch in 300mL of deionized water, heat and stir at 80°C until clear and transparent; dissolve 10g of nepetalactone in 100mL of absolute ethanol, preheat, Then add the solution dropwise into the porous starch solution, and keep stirring for 2 hours, then add the gelatin solution and continue stirring for 1.5 hours, and finally obtain a coarse emulsion containing nepetalactone microcapsules. The above emulsion is spray-dried, the conditions are: the feed flow rate is 70ml / min, and the drying air flow rate is 70m 3 / h, the hot air inlet temperature is 190°C, and the outlet temperature is 65°C.

Embodiment 3

[0059] Dissolve 80g of gelatin in 400mL of deionized water, 40g of porous starch in 200mL of deionized water, heat and stir at 75°C until clear and transparent; dissolve 7g of nepetalactone in 75mL of absolute ethanol, preheat, Then the solution was added dropwise into the porous starch solution, and kept stirring for 2.5 hours, then added the gelatin solution and continued to stir for 3 hours, and finally obtained a coarse emulsion containing nepetalactone microcapsules. The above emulsion is spray-dried, the conditions are: the feed flow rate is 70ml / min, and the drying air flow rate is 80m 3 / h, the hot air inlet temperature is 180°C, and the outlet temperature is 70°C.

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Abstract

The invention relates to the technical field of daily chemical products, and particularly relates to nepetalactone microcapsules, a preparation method thereof and application of the nepetalactone microcapsules in preparation of mosquito-repelling products. According to the nepetalactone microcapsules provided by the invention, each microcapsule adopts nepetalactone adsorbed porous starch as a core material, then, gelatin is used for carrying out embedding, and thus, the formed microcapsules are stable and have good sustained-release property, so that the volatilization of nepetalactone is reduced, the mosquito repelling time is prolonged, and the mosquito repelling rate is increased. A humulus scandens extract, a herba violae extract and pure rose dew in mosquito-repelling gel provided by the invention further have the effects of resisting allergies, resisting inflammation, relieving itching and reducing swelling, and the irritation to skin is reduced, so that the mosquito-repelling gel has better safety and a more efficient mosquito repelling effect. Shown by experiments, in case of a proper proportioning ratio, the effective mosquito-repelling time of the mosquito-repelling gel provided by the invention can reach 13.7h, and the effective mosquito repelling rate can still reach 84.6% after the mosquito-repelling gel is used for 18h.

Description

technical field [0001] The invention relates to the technical field of daily chemicals, in particular to nepetalactone microcapsules, a preparation method thereof and an application in preparing mosquito repellent products. Background technique [0002] In addition to direct stings and harassment, the main harm of mosquitoes to human beings is that they can spread various diseases. Since the beginning of the last century, mosquitoes have received great attention as an important disease vector. Arbovirus diseases such as yellow fever, dengue fever, Toxic fever, Eastern equine encephalitis, Western equine encephalitis, Venezuelan equine encephalitis, Japanese encephalitis, and Ross River fever have all been proved to be transmitted by mosquitoes. At present, in mosquito products, due to the extensive use of chemical insecticides, problems such as drug resistance and environmental pollution have been caused. More importantly, their chemical components are reabsorbed through th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/11A61K8/04A61K8/9789A61K8/49A61K8/65A61K8/73A61Q17/04
CPCA61K8/042A61K8/11A61K8/498A61K8/65A61K8/732A61K8/97A61Q17/04
Inventor 魏坤王晓慧秦烨芝胡露谢水林
Owner 广州睿森生物科技有限公司