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Composition containing phytic acid, magnesium and polyphenols for the treatment or prevention of renal lithiasis

A composition and technology of phytic acid, applied in the field of pharmacology, can solve the problems of increasing difficulty in crystallization of calcium oxalate, reducing supersaturation of calcium oxalate and the like

Active Publication Date: 2017-03-22
UNIV DE LAS ISLAS BALEARES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Thus, magnesium significantly reduces calcium oxalate supersaturation by forming a soluble complex with oxalate ions, which leads to increased difficulty in generating calcium oxalate crystals

Method used

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  • Composition containing phytic acid, magnesium and polyphenols for the treatment or prevention of renal lithiasis
  • Composition containing phytic acid, magnesium and polyphenols for the treatment or prevention of renal lithiasis
  • Composition containing phytic acid, magnesium and polyphenols for the treatment or prevention of renal lithiasis

Examples

Experimental program
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Effect test

example 1

[0040] Example 1. Measurement of calcium oxalate crystallization in the presence of magnesium and phytate.

[0041] From 200 mg / L calcium and 50 mg / L oxalate solutions, the induction time for calcium oxalate crystallization in synthetic urine has been calculated in the presence of different phytate and / or magnesium concentrations. Table 1 shows the induction times, as determined by figure 1 As clearly seen in , the induction time increased with increasing concentrations of magnesium and phytate. Thus, calcium oxalate takes 1 minute to crystallize when no magnesium or phytate is present. This time increases up to 10 minutes when 100 mg / L magnesium is added and, in turn, up to 44 minutes if 1 mg / L phytate is added in addition to 10 mg / L magnesium.

[0042] Table 1 : Crystallization induction times (in minutes) for 200 mg / L calcium and 50 mg / L oxalate solutions in synthetic urine at different magnesium and phytate concentrations.

[0043]

example 2

[0044] Example 2. Effect of a composition of the invention on Wistar rats subjected to a calculigenic diet.

[0045] A group of Wistar rats were treated with polyphenols extracted from white grape seeds (added to drinking water at a concentration of 200mg / L) and phytate (1% of the solid diet fed to the animals, in the form of calcium magnesium phytate, The calcium magnesium phytate is calcium magnesium salt) for pretreatment. Subsequently, papillary nephrolithiasis was induced by administration of ethylene glycol, and prophylactic treatment was continued. The anticalculus activity of the polyphenol + phytate mixture was assessed by the calcium content of the kidneys (extracted at the end of the experiment) of the animals and by the corresponding histological study of the kidney tissue by comparison with the corresponding control group. A 50% reduction in renal calcification was observed with the applied prophylactic treatment.

example 3

[0046] Example 3. The effect of the composition of the invention on a patient with nephrolithiasis problem.

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Abstract

The invention relates to a composition containing phytic acid or a phytate salt, magnesium in the form of salt, hydroxide or oxide and optionally at least one polyphenol. These compounds can be in the isolated form or form part of an enriched plant extract. The invention also relates to the use of this composition for the treatment of renal lithiasis, preferably calcium or oxocalcium, in the form of a drug, nutraceutical or functional food, or food supplement.

Description

technical field [0001] The present invention relates to a composition comprising phytic acid or any of its phytate salts, a magnesium salt and optionally a polyphenol, useful for the treatment of nephrolithiasis, mainly calcium nephrolithiasis, due to its composition The synergistic effect between the components to inhibit the crystallization of calcium salts, the reduction of free oxalate and papillary damage due to oxidative stress. [0002] Accordingly, the present invention belongs to the field of pharmacology. Background technique [0003] Ionic species of phytic acid (phytate) are known to have the ability to inhibit the development of calcium salt deposits in biological fluids, thus reducing the risk of both calcium kidney stones and other pathological calcifications. Phytate is also known to be found in the tissues and fluids of mammals primarily from the diet. Recently, it has been shown that calcium oxalate monohydrate papillary kidney stones occur due to injury ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/08A61K33/10A61K33/06A61K31/6615A61K36/87A61P13/04A61K31/194A61K31/20
CPCA61K31/194A61K31/20A61K31/6615A61K33/06A61K33/08A61K33/10A61K36/87A61K2300/00A61K45/06A61K31/05A61K31/192A61K31/353A61K31/7024A23L33/105A61P13/04A61P13/12A23L29/035A23L29/015A23L29/30A61K36/48A61K36/899
Inventor F·格拉塞斯弗雷谢达什A·科斯塔鲍萨R·M·普列托阿尔米拉利A·罗德里格斯罗德里格斯
Owner UNIV DE LAS ISLAS BALEARES
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