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A small molecule marker of plasma metabolism related to cholelithiasis and its application

A technology for metabolizing small molecules and cholelithiasis, applied in the fields of analytical chemistry and clinical medicine, it can solve the problems of complex experimental steps and low sensitivity, and achieve the effect of improving sensitivity and specificity, high sensitivity and specificity, and accurate quantification.

Active Publication Date: 2019-05-14
NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

NMR technology is characterized by no damage to the components to be measured, simple sample pretreatment, but low sensitivity; gas chromatography-mass spectrometry has good sensitivity and reproducibility, but derivatization methods are generally used for sample pretreatment , making the experimental steps more complicated

Method used

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  • A small molecule marker of plasma metabolism related to cholelithiasis and its application
  • A small molecule marker of plasma metabolism related to cholelithiasis and its application
  • A small molecule marker of plasma metabolism related to cholelithiasis and its application

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Embodiment 1

[0084] Study object selection and grouping basis

[0085] The present invention collected the blood of cholelithiasis and normal non-cholelithiasis individuals meeting the requirements from the Cholelithiasis Center of Shanghai Dongfang Hospital Affiliated to Tongji University from July 2011 to June 2012 ( Figure 1A and Figure 1B : for gallbladder stones seen by ultrasound and naked eyes), through sorting out the sample data, 200 cases of healthy controls (average age: 45.1±6.3 years old), 200 cases of cholelithiasis patients (average age: 46.5±6.3 years old) and 200 cases of cholelithiasis patients (average age: 5.2 days) as a screening test object for cholelithiasis metabolic small molecule biomarkers. Specific sample classification standards are as follows: specific sample classification

[0086] The class standards are as follows:

[0087] Group A: healthy control group (n=100, 75 people screened, 25 people verified by independent population):

[0088] 1. Age 25-70 ye...

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PUM

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Abstract

The invention relates to a cholelithiasis related blood plasma metabolism micro-molecular marker and an application thereof. The marker is trimethylamine oxide and trimethylamine. Metabolism micro-molecules of normal contrast blood plasma and cholelithiasis patient's blood plasma are compared through adopting UPLC-Q exactive MS to find the blood plasma metabolism micro-molecular marker combination used for assessing that whether a patient is suffering from cholelithiasis and having diagnosis values in the blood plasma. A cholelithiasis diagnosing and monitoring kit convenient for clinic application is developed through applying the UPLC-Q exactive MS detected by the blood plasma metabolism micro-molecular marker.

Description

technical field [0001] The invention belongs to the field of analytical chemistry and clinical medicine, and relates to a marker for assisting early diagnosis of cholelithiasis and screening of high-risk groups and its application, and is characterized in detecting metabolic small molecule markers related to cholelithiasis and its application. Background technique [0002] Cholelithiasis is a common disease worldwide. In the past 20 years, with the popularization of imaging (B-mode ultrasound, CT and MRI, etc.), many asymptomatic cholelithiasis will also be found in physical examination. In my country, with economic development and improvement of living standards, its incidence rate increases year by year, and increases with age, especially gallstones. Recent epidemiological surveys show that in the natural population, the incidence of gallbladder stones is close to 15%. Gallbladder stones are mainly seen in adults, more women than men, and the incidence rate increases sig...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/60
CPCG01N30/02G01N30/6091
Inventor 顾爱华蒋兆彦徐诚刘倩郭文慧
Owner NANJING MEDICAL UNIV
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