61results about How to "Delay and stop disease progression" patented technology

The invention belongs to the fields of gene engineering and clinical medicine, and discloses a plasma micro-ribonucleic acid (miRNA) marker related with a human Hirschsprung's disease and application of the miRNA marker. The marker is selected from multiple kinds of hsa-miR-34b, hsa-miR-31*, hsa-miR-141 and hsa-miR-194. The marker has specificity and sensitivity on the Hirschsprung's disease, canbe used for preparing a reagent for diagnosing or monitoring the Hirschsprung's disease, can avoid invasive diagnosis, can be used for screening and diagnosis at the early stage, can be repeatedly detected, and is easy in dynamic monitoring.

The invention belongs to the fields of genetic engineering and clinical medicine, and discloses a related serum microribonucleic acid marker for human severe preeclampsia and application of the marker. The marker is selected from more of hsa-miR-193a-5p, hsa-miR-424 and hsa-miR-10a. The marker has the specificity and sensitivity on a sufferer with severe preeclampsia, and can be used for preparing a diagnosis or monitoring kit for severe preeclampsia.

The invention belongs to the field of analytic chemistry and clinical medicine and discloses a fetal macrosomia auxiliary diagnostic marker and application thereof. The marker is the combination of nicotinamide and citric acid and can be used for manufacturing a fetal macrosomia diagnosing or monitoring kit. The marker has the better auxiliary diagnostic effect on fetal macrosomia, can lower the detection cost and reduce economical burdens of a patient and is beneficial to clinical usage and popularization.

The invention belongs to the field of analytical chemistry and clinical medicine and discloses an idiopathic male infertility-related medium-chain fatty acid marker in serum and a detection method and application thereof. The marker is capric acid and/or lauric acid, and an UPLC-Q exactive MS method is adopted for detection. The marker can be used for auxiliary diagnosis and monitoring of idiopathic male infertility, has high sensitivity and specificity, and has clinic promotion value.

The invention belongs to the fields of analytical chemistry and clinical medicine, and discloses an idiopathic male infertility-related seminal plasma metabolic small molecular marker as well as a detection method and application thereof. The marker is prepared from seminal plasma metabolic small molecular acetylcarnitine and/or tryptophan, and is detected by adopting a UPLC-Q exactive MS method; the marker can be used for auxiliary diagnosis and monitoring of the idiopathic male infertility, and has higher sensitivity and specificity, thus having a clinical popularization value.

Belonging to the field of analytical chemistry and clinical medicine, the invention discloses an idiopathic male infertility related steroid hormone marker in serum, a detection method and application thereof. The marker is cortisol and/or dehydroepiandrosterone, a UPLC-Q exactive MS method is employed for detection, the marker can be used for auxiliary diagnosis and monitoring of idiopathic male infertility, has high sensitivity and specificity, and has clinical promotion value.

The invention belongs to the field of gene engineering, and discloses mitochondrion correlation serum micro ribonucleic acid serving as markers of human obesity occurrence and application thereof. The markers are some miRNA which is mitochondrion correlation miRNA and is selected from hsa-miR-141-3p, hsa-miR-196a-5p, hsa-miR-210-3p, hsa-miR-378a-3p, hsa-miR-484 and hsa-miR-499a-5p. Obesity cases and normal body weight can be well contrasted and separated, and the markers can be used for preparing obesity diagnosing or monitoring kits.

The invention belongs to the fields of analytical chemistry and clinical medicine and discloses a plasma metabolism micromolecular marker related to human intestinal canal aganglionosis and an application of the plasma metabolism micromolecular marker. The plasma metabolism micromolecular marker is one or more than one of phenylpropyl tryptophan, succinyl carnitine and gamma-glutamoyl glutamic acid. The plasma metabolism micromolecular marker has specificity and sensibility on intestinal canal aganglionosis. A kit provided by the invention adopts UPLC-MS (ultra performance liquid chromatography-mass spectrometry) and can accurately detect phenylpropyl tryptophan, succinyl carnitine and gamma-glutamoyl glutamic acid in plasma, better auxiliary information can be provided for diagnosing intestinal canal aganglionosis, invasive diagnosis can be avoided, screening and diagnosis can be carried out in early stage, repeated detection can be realized, and dynamic monitoring is easy to realize.

The invention belongs to the field of analytic chemistry and clinical medicine, and discloses a metabolism marker related to idiopathic male infertility in urine, and a detection method and application thereof. The metabolism marker is L-leucine and/or L-palmitoyl carnitine, is detected by adopting UPLC-Qexactive MS method, can be used for auxiliary diagnosis and monitoring of idiopathic male infertility, has higher sensitivity and specificity, and has a clinical spread value.

The invention relates to a biomarker for abnormal invasion of trophoblast cells and application thereof. It is proved that miR-181b is generally and differentially expressed in pregnancy-related disease tissue with abnormal trophoblast invasion, and S1PR1 is a direct effect target gene of miR-181b; and the discovery of the influence of a miR-181b-S1PR1 pathway on the molecular mechanism of the invasion ability of trophoblast cells provides new clues and potential intervention targets for the prevention and treatment of pregnancy-related diseases caused by abnormal trophoblast invasion.

The invention belongs to the field of analytical chemistry and clinical medicine and discloses the urine estrogen metabolite markers related to idiopathic male infertility and the detection methods and application. The marker is the urine estrogen metabolite 2-methoxyestradiol and/or androstenedione and detected by UPLC Q exactive MS method. The urine estrogen metabolite markers related to idiopathic male infertility can be used for auxiliary diagnosis and monitoring of idiopathic male infertility, and has high sensitivity, specificity, and clinical spread value.

The invention belongs to the fields of analytical chemistry and clinical medicine, and discloses a capric acid and prostaglandin E2 combination as a giant baby auxiliary diagnosis marker and the application thereof. The auxiliary diagnosis marker is a combination of micromolecular capric acid and prostaglandin E2, can be used for preparing a giant baby auxiliary diagnosis or monitoring kit, is relatively high in sensitivity and specificity and rapid in detection, and has a relatively high clinical application value.

The invention belongs to the fields of genetic engineering and clinical medicines, and discloses a plasma miRNA (micro ribonucleic acid) marker associated with common type congenital intestinal canal total colonic aganglionosis and an application thereof. The marker is selected from more of hsa-miR-31, hsa-miR-147 and hsa-miR-206. The marker has specificity and sensitivity to the common type congenital intestinal canal total colonic aganglionosis, can be used for the preparation of reagents for diagnosing or monitoring the common type congenital intestinal canal total colonic aganglionosis, can avoid invasive diagnosis, can be used for screening and diagnosis in an early stage, and can be used for detecting repeatedly and is easy for dynamic monitoring.

The invention belongs to the field of analytical chemistry and clinical medicine, and discloses an application of lead and cadmium mixing exposure detection in an assistant diagnosis of azoospermia. An exposed biomarker associated with the azoospermia is the mixing exposure of the lead and the cadmium. The concentration of the lead and the cadmium in whole blood can be detected by ICP-MS (Inductively Coupled Plasma Mass Spectrometry), which can be used for the assistant diagnosis of the azoospermia. The application of the lead and the cadmium mixing exposure detection in the assistant diagnosis of the azoospermia has the advantages of less blood volume, simple operation, fast, accurate, and good clinical promotion value.

The invention belongs to the technical field of medical biology, and discloses an esophageal squamous cell carcinoma early screening marker based on metabonomics and a kit thereof. The marker for screening the esophageal squamous cell carcinoma, provided by the invention, is at least one of N-o-tolueneglycine, D-sorbitol and N-acetyl-D-mannosamine, and a detection reagent of the marker can be used for preparing a product for screening the esophageal squamous cell carcinoma. The invention also provides a kit for screening esophageal squamous carcinoma. The kit contains a detection reagent for detecting the marker. According to the kit, the esophageal squamous cell carcinoma, especially the early esophageal squamous cell carcinoma, can be effectively detected by detecting the expression levels of N-o-tolueneglycine, D-sorbitol and N-o-tolueneglycine in human serum; and when the three markers are combined, the detection sensitivity reaches up to 92.2%, the specificity reaches 98.0%, and the kit can be used for large-scale screening of asymptomatic crowds in high-incidence areas of esophageal squamous carcinoma and is beneficial to screening and early discovery of asymptomatic high-risk crowds.

The invention belongs to the fields of analytical chemistry and clinical medicine and discloses a detecting method of a lead-cadmium mixed-exposure marker related to sex-hormone abnormality and an application thereof. The lead-cadmium mixed-exposure marker related to sex-hormone abnormality is the lead-cadmium mixed-exposure marker. The detecting method adopts ICP-MS to detect the concentration oflead and cadmium in whole blood, can be used for auxiliary diagnosis on the sex-hormone abnormality, is less in blood use amount, is simple, fast and accurate in operation and has better clinical promotion value.

The invention discloses an ICP-MS-based mercury and arsenic mixed exposure test low-birth-weight auxiliary diagnosis marker and application thereof and belongs to the fields of analytic chemistry andclinical medicine. The ICP-MS-based mercury and arsenic mixed exposure test low-birth-weight auxiliary diagnosis marker, namely, a low-birth-weight related exposure biomarker, is a mixture of mercuryand arsenic and applies an ICP-MS-based detecting method. Comparison of the mercury and arsenic mixed exposure levels in normal contrast whole blood and the whole blood of a low-birth-weight case through ICP-MS helps discover that man's whole blood contains a marker combination applicable to assessing risk low-birth-weight and achieving auxiliary diagnosis values. The invention also relates to application of ICP-MS of detection of the ICP-MS-based mercury and arsenic mixed exposure test low-birth-weight auxiliary diagnosis marker to help develop a low-birth-weight auxiliary diagnosis kit applicable to clinical application.