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Calcium fluoride collagen microfiber complex and preparation method thereof

A technology of collagen fibers and calcium fluoride, applied in the fields of fiber chemical characteristics, rayon manufacturing, single-component protein rayon, etc., can solve the problem of not obtaining complex structures of nano-grains, and achieve the promotion of internal mineral growth and pollution The effect of less energy consumption

Active Publication Date: 2018-11-23
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, relevant scholars have not obtained the complex structure of nanocrystalline grain assembly at the collagen microfibril level

Method used

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  • Calcium fluoride collagen microfiber complex and preparation method thereof
  • Calcium fluoride collagen microfiber complex and preparation method thereof
  • Calcium fluoride collagen microfiber complex and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Preparation of calcium fluoride collagen microfibril complex, the steps are as follows:

[0063] 1) Collagen pretreatment: Add 20 mg of collagen fiber powder into acetic acid solution with a concentration of 0.1 M, stir well for 24 hours to obtain a collagen solution with a concentration of 2 mg / mL, and store the obtained collagen solution at 4°C for 24 hours , and then 20 μ L of the prepared collagen solution was evenly coated on the surface of the substrate (the size of the glass sheet was 18×18 mm, and the thickness was 0.13-0.17 mm), and the substrate and the ammonia solution with a volume fraction of 25% were placed on 2 Place the two small glass dishes together in a large glass dish and seal them with plastic wrap, and let them stand for 12 hours to allow the collagen solution to diffuse and assemble on the surface of the substrate to form collagen microfibers to obtain a collagen substrate. ;

[0064] 2) Synthesis of calcium fluoride precursor solution: mix and ...

Embodiment 2

[0068] Preparation of calcium fluoride collagen microfibril complex, the steps are as follows:

[0069] 1) Collagen pretreatment: Add 20 mg of collagen fiber powder into acetic acid solution with a concentration of 0.1 M, stir well for 24 hours to obtain a collagen solution with a concentration of 2 mg / mL, and store the obtained collagen solution at 4°C for 24 hours , and then 20 μ L of the prepared collagen solution was evenly coated on the surface of the substrate (the size of the glass sheet was 18×18 mm, and the thickness was 0.13-0.17 mm), and the substrate and the ammonia solution with a volume fraction of 25% were placed on 2 Place the two small glass dishes together in a large glass dish and seal them with plastic wrap, and let them stand for 12 hours to allow the collagen solution to diffuse and assemble on the surface of the substrate to form collagen microfibers to obtain a collagen substrate. ;

[0070] 2) Synthesis of calcium fluoride precursor solution: mix and ...

Embodiment 3

[0074] Preparation of calcium fluoride collagen microfibril complex, the steps are as follows:

[0075] 1) Collagen pretreatment: Add 20 mg of collagen fiber powder into acetic acid solution with a concentration of 0.1 M, stir well for 24 hours to obtain a collagen solution with a concentration of 2 mg / mL, and store the obtained collagen solution at 4°C for 24 hours , and then 20 μ L of the prepared collagen solution was evenly coated on the surface of the substrate (the size of the glass sheet was 18×18 mm, and the thickness was 0.13-0.17 mm), and the substrate and the ammonia solution with a volume fraction of 25% were placed on 2 Place the two small glass dishes together in a large glass dish and seal them with plastic wrap, and let them stand for 12 hours to allow the collagen solution to diffuse and assemble on the surface of the substrate to form collagen microfibers to obtain a collagen substrate. ;

[0076] 2) Synthesis of calcium fluoride precursor solution: mix and ...

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Abstract

The invention relates to a calcium fluoride collagen micro-fiber composite and a preparation method thereof. The preparation method includes the steps of: (1) adding collagen protein fiber powder to an acetic acid solution to prepare a collagen protein solution, and uniformly coating a surface of a substrate with the collagen protein solution and diffusing the collagen protein solution with ammonia water to produce a collagen substrate; (2) uniformly mixing and stirring sodium fluoride, sodium chloride and water to prepare a solution A, uniformly mixing and stirring calcium chloride, a polyacrylic acid solution, 4-hydroxyethyl piperazine ethanesulfonic acid and water to obtain a solution B, slowly adding the solution A dropwise to the solution B and regulating the pH of the system to prepare a calcium fluoride precursor solution; and (3) soaking the collagen substrate in the calcium fluoride precursor solution for mineralization to prepare the calcium fluoride collagen micro-fiber composite. The method for producing the calcium fluoride collagen micro-fiber composite is carried out through internal mineralization of the collagen micro-fibers at normal temperature and under normal pressure, thereby achieving internal mineralization of the collagen micro-fibers.

Description

technical field [0001] The invention relates to the field of biomineralization, in particular to a method for preparing calcium fluoride collagen microfiber complexes by mineralizing collagen microfibers. Background technique [0002] Biomineralization refers to the process of synthesizing highly fine organic-inorganic hybrid structures in organisms, such as bones, teeth, shells, etc., and its essence is the process of mineral growth in organisms. Biominerals refer to the composite substances produced by the above process that contain minerals and organic substrates and are assembled according to a certain ordered structure. [0003] Although there are many problems to be solved in the study of the mineralization mechanism, the mineralization model is universal: the matrix is ​​composed of a hydrophobic cross-linked structure framework, and hydrophilic macromolecules are immobilized on the surface. Aqueous macromolecules can provide active nucleation surfaces for external s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01F4/00D01F1/10
CPCD01F1/10D01F4/00
Inventor 傅正义方微渐平航谢浩王为民王皓王玉成
Owner WUHAN UNIV OF TECH
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