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Preparation method of high-sensitivity mirtazapine molecularly-imprinted electrochemical sensor

A molecular imprinting and high-sensitivity technology, applied in scientific instruments, instruments, analytical materials, etc., can solve problems such as low sensitivity, inappropriate matching of functional monomers, template molecules and cross-linking agents, poor cross-linking rigidity, etc., to achieve Simple equipment, excellent sensitivity, and easy-to-make effects

Inactive Publication Date: 2017-04-26
GUANGXI UNIV FOR NATITIES
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AI Technical Summary

Problems solved by technology

The current method is not sensitive due to the inappropriate matching of selected functional monomers with template molecules and cross-linking agents, and the rigidity of cross-linking is also poor.

Method used

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  • Preparation method of high-sensitivity mirtazapine molecularly-imprinted electrochemical sensor

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Embodiment 1

[0015] 1. Treatment of glassy carbon electrodes

[0016] Polish the glassy carbon electrode on a polishing cloth with 1.0 μm, 0.3 μm and 0.05 μm alumina powder in sequence, then put it into nitric acid with a volume ratio of 1:1 for 6 minutes, then put it into absolute ethanol for 6 minutes, and finally Ultrasonic cleaning with pure water.

[0017] 2. Preparation of Molecularly Imprinted Electrochemical Sensor for Mirtazapine

[0018] use water as a solvent to prepare 10ml of nickel sulfate aqueous solution with a concentration of 0.5mol / L, and use N, N-dimethylformamide as a solvent to prepare 50ml of a salicylic acid solution with a concentration of 0.05mol / L, and then take the prepared Add 10ml of nickel sulfate aqueous solution dropwise to the prepared 50ml of salicylic acid solution at a rate of 5 drops / second, stir vigorously at a speed of 3000 rpm during the dropwise addition, and then react in a 100ml hot water kettle at 118°C 11 hours, after cooling, the resulting ...

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Abstract

The invention discloses a preparation method of a high-sensitivity mirtazapine molecularly-imprinted electrochemical sensor. The high-sensitivity mirtazapine molecularly-imprinted electrochemical sensor is prepared by taking mirtazapine as template molecules, taking resveratrol as a functional monomer, taking azodiisobutyronitrile as an initiator, taking a nickel-based metal organic framework material as a doping agent and taking isoalantolactone as a crosslinking agent. The analysis method is simple and practical, and the defects of being complex, expensive in equipment and low in sensitivity of an original analysis method are overcome.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a preparation method of a high-sensitivity mirtazapine molecularly imprinted electrochemical sensor. Background technique [0002] Mirtazapine (Remeron) is an antidepressant and an antagonist of central presynaptic α2 receptors, which can enhance adrenergic nerve transmission. It simultaneously blocks central 5-HT2 and 5-HT3 receptors: both enantiomers of mirtazapine have antidepressant activity, the L-isomer blocks α2 and 5-HT2 receptors, and the D-isomer blocks 5-HT2 receptors. -HT3 receptors. The antihistamine receptor (H1) properties of mirtazapine act as a sedative. The drug is well tolerated, has almost no anticholinergic effect, and has no effect on the cardiovascular system. Mirtazapine is indicated for depression and is effective for symptoms such as anhedonia, psychomotor depression, poor sleep (early awakening), and weight loss. However, long-term u...

Claims

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Application Information

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IPC IPC(8): G01N27/333
CPCG01N27/3335
Inventor 余会成李浩韦贻春
Owner GUANGXI UNIV FOR NATITIES
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