Preparation method of valpromide molecular imprinting electrochemical sensor

A provalerenamide, molecular imprinting technology, applied in the direction of electrochemical variables of materials, scientific instruments, instruments, etc., can solve the problems that functional monomers and template molecules cannot be properly matched, the sensitivity is not high, and the cross-linking rigidity is poor. Achieving excellent sensitivity, simple equipment, and easy production

Inactive Publication Date: 2018-04-20
GUANGXI UNIV FOR NATITIES
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Problems solved by technology

The current method is not sensitive because the selected functional monomers cannot be prope

Method used

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  • Preparation method of valpromide molecular imprinting electrochemical sensor

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[0013] Example 1

[0014] 1. Treatment of glassy carbon electrode

[0015] Polish the glassy carbon electrode on the polishing cloth with 1.0 μm, 0.3 μm and 0.05 μm alumina powder, then put it in a 1:1 volume ratio of nitric acid and sonicate for 8 min, then put it in absolute ethanol for 8 min , And finally clean with pure water ultrasonic cleaning.

[0016] 2. Preparation of Avaleramide Molecularly Imprinted Electrochemical Sensor

[0017] To 10.0 mL of solvent ethanol, add 1.0 mmol template molecule avaleramide, 4.0 mmol functional monomer young branch containing severed loganin, 4.0 mmol crosslinker N-trans-ferulotyramide, 0.11 mmol initiator Azobisisobutyronitrile and 0.0500 g of nanoclay are dissolved by ultrasonic for 8 minutes each time a chemical reagent is added;

[0018] Take steps Apply 8 μL of the mixture on a clean and smooth glassy carbon electrode surface with a diameter of 2 mm. After leaving it for 6 hours, place the modified electrode in a vacuum drying oven at 8...

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Abstract

The invention discloses a preparation method of a valpromide molecular imprinting electrochemical sensor. The high-sensitivity valpromide molecular imprinting electrochemical sensor doped with nanometer clay is prepared by using valpromide as a template molecule, secoxyloganin as a functional monomer, azodiisobutyronitrile as an initiating agent, nanometer clay as a doping agent and N-trans-feruloyltyramine as a cross-linking agent. The analysis method is simple and practical; the defects of complexity, expensive equipment and low sensitivity of a conversional analysis method are overcome.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a preparation method of a valerenamide molecularly imprinted electrochemical sensor. Background technique [0002] Valpromide, also known as dipropylacetamide. It is a new type of antiepileptic drug with broad spectrum, strong effect and quick effect. It has broad anticonvulsant effect without excitement and has sedative effect. It can be used for the treatment of various types of epilepsy. The main disadvantage is that long-term or excessive use of such drugs can cause liver and kidney damage and lupus erythematosus. [0003] The methods for determination of valerenamide include gas chromatography, gas phase-mass spectrometry, high performance liquid chromatography gradient elution method and solid phase extraction chromatography, etc. However, due to the need for expensive instruments and equipment, these methods have disadvantages such as high cost, long time...

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Application Information

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IPC IPC(8): G01N27/30G01N27/48
CPCG01N27/308G01N27/48
Inventor 陈其锋马祥英余会成刘绍刚韦贻春
Owner GUANGXI UNIV FOR NATITIES
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