Medical aerosol preparation and quantitatively-inhaled aerosol
A quantitative inhalation and aerosol technology, which is used in aerosol delivery, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Delivering dose uniformity and other issues to achieve the effect of reducing the dose and increasing the stability of the liquid
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Embodiment 1
[0026] A medical aerosol preparation, comprising an active ingredient and a liquefied propellant as a solvent for the active ingredient, the active ingredient including mometasone furoate and formyl fumarate, the liquefied propellant is hydrofluorocarbon, and It includes ethanol and Span 80 added to the liquefied propellant, and the weight ratio of the Span 80 in the aerosol formulation is 0.01%-0.1% w / w.
[0027] Specifically, in view of the above-mentioned problem that ethanol affects the uniformity of drug delivery dose, in the prior art, oleic acid is added to aerosol preparations. However, as the aerosol preparation is placed for a longer time, the uniformity of drug delivery dose gradually deteriorates.
[0028] In this solution, by adding Span 80 as a surfactant to the aerosol formulation, the Span 80 can maintain a uniform concentration of the drug solution for a long time, thereby achieving the purpose of increasing the stability of the drug solution. The above limitation ...
Embodiment 2
[0050] This embodiment is further limited on the basis of Embodiment 1. As a further technical solution of the medical aerosol preparation described above, the effective components in the aerosol preparation can be effectively divided or deposited in the bronchus, On the bronchioles and lungs, the mometasone furoate and the fumarate fumarate are all fine powders with a median particle size less than 5 microns obtained after airflow pulverization. In this solution, since a certain amount of Span 80 is added to the aerosol formulation, although the effective ingredients with the median particle size above have a large surface energy, they are still not easily adsorbed on the surface of the container.
[0051] As a solution for realizing a liquefied propellant that is beneficial to environmental protection, the HFC is any one of HFA 134a and HFA 227 or a mixture of both.
Embodiment 3
[0053] This embodiment is further limited on the basis of Embodiment 1. As a further technical solution of the above medical metered dose inhalation aerosol, the pressurized metered-dose inhaler includes a container 1, a metering valve 2 and a driver 3. The material of the containing tank 1 is magnesium-aluminum alloy, and part or all of the inner wall of the containing tank 1 is coated with perfluorocarbon high polymer.
[0054] The above containing tank 1 is used as a storage container for aerosol preparations. Because the natural oxide film on the surface of the ordinary magnesium aluminum alloy is thin and soft, the density is poor, the surface is uneven, and it is easy to absorb the particles in the drug, and the surface layer of the tank 1 is also contained The magnesium, aluminum, etc. will penetrate into the liquid medicine. In this solution, the inner wall of the containing tank 1 is partially or completely coated with perfluorocarbon polymer, so that a dense coating can...
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