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A photosensitive pharmaceutical preparation for photodynamic sterilization and its application

A photosensitive drug and photodynamic technology, applied in photodynamic therapy, antibacterial drugs, drug combinations, etc., can solve the problems of narrow antibacterial spectrum and reduced antibacterial effect

Active Publication Date: 2021-06-29
郑州嘉泰生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Because quaternary ammonium salt disinfectants have few side effects, are colorless, odorless, less irritating, and are low-toxic and safe, they are widely used as preservatives and disinfectants in cosmetics, disinfection products and medicines. However, early quaternary ammonium Salt disinfectants have the disadvantages of narrow antibacterial spectrum, being easily affected by anionic active agents, water quality, protein and other organic matter, thus reducing the antibacterial effect.

Method used

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  • A photosensitive pharmaceutical preparation for photodynamic sterilization and its application

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0016] Methylene Blue Gel A: 0.01% w / v methylene blue and other suitable pharmaceutically acceptable carriers.

[0017] Methylene blue gel B: 0.01% w / v methylene blue, 0.2% double long-chain quaternary ammonium salt, and other suitable pharmaceutically acceptable carriers are the same as those of methylene blue gel A.

[0018] Gel C: 0.2% double-chain quaternary ammonium salt, other suitable pharmaceutically acceptable carriers are the same as methylene blue gel A.

[0019] Gel blank: does not contain methylene blue and double-chain quaternary ammonium salt, and other suitable pharmaceutically acceptable carriers are consistent with methylene blue gel A.

[0020] The methylene blue monomer can be photochemically excited into a triploid form with a high quantum yield, thereby further transferring energy to molecular oxygen to obtain singlet oxygen, which is considered to be the main active oxygen component in the photodynamic sterilization process. Polymers such as methylene b...

specific Embodiment 2

[0027] Methylene blue solution A: 0.01% w / v methylene blue and other suitable pharmaceutically acceptable carriers.

[0028] Methylene blue solution B: 0.01% w / v methylene blue, 0.2% chitosan quaternary ammonium salt, other suitable pharmaceutically acceptable carriers are the same as methylene blue solution A.

[0029] Solution C: 0.2% chitosan quaternary ammonium salt, other suitable pharmaceutically acceptable carriers are the same as methylene blue solution A.

[0030] Blank solution: does not contain methylene blue and chitosan quaternary ammonium salt, and other suitable pharmaceutically acceptable carriers are consistent with methylene blue solution A.

[0031] According to the Chinese Pharmacopoeia appendix spectrophotometry in the range of 200nm-800nm ​​UV scanning, UV scanning results show that: methylene blue solution A compared with methylene blue solution B, the content of methylene blue monomer in methylene blue solution A is lower, chitosan quaternary ammonium s...

specific Embodiment 3

[0038] Methylene blue ointment A: 0.01% w / v methylene blue and other suitable pharmaceutically acceptable carriers.

[0039] Methylene blue ointment B: 0.01% w / v methylene blue, 0.2% polymeric quaternary ammonium salt, and other suitable pharmaceutically acceptable carriers are the same as in methylene blue ointment A.

[0040] Ointment C: 0.2% polymeric quaternary ammonium salt, other suitable pharmaceutically acceptable carriers are the same as methylene blue ointment A.

[0041] Blank ointment: does not contain methylene blue and polymeric quaternary ammonium salts, and other suitable pharmaceutically acceptable carriers are the same as methylene blue ointment A.

[0042] According to the Chinese Pharmacopoeia appendix spectrophotometry in the range of 200nm-800nm ​​UV scanning, UV scanning results show that: methylene blue ointment A compared with methylene blue ointment B, the content of methylene blue monomer in methylene blue ointment A is lower, polymerized quaternary ...

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Abstract

The present invention relates to a photosensitive pharmaceutical preparation for photodynamic sterilization and its use. The photosensitive pharmaceutical preparation for photodynamic sterilization consists of a photosensitizer, at least one quaternary ammonium salt, a viscosity regulator, a pH value regulator, a stabilizer Other pharmaceutically acceptable carriers such as agents, excipients and other pharmaceutically acceptable carriers are made of photosensitive pharmaceutical preparations through appropriate preparation techniques. The present invention also relates to the use of photosensitive pharmaceutical preparations for photodynamic sterilization: applying them to the target treatment area in an appropriate manner Photosensitive pharmaceutical preparations that apply light to the target treatment area at the wavelength of maximum absorption of the photosensitizer, thereby killing Gram-positive bacteria, Gram-negative bacteria, yeasts, fungi, and parasitic protists in the target treatment area pathogenic microorganisms. Wherein the quaternary ammonium salt has a synergistic antimicrobial effect on pathogenic microorganisms such as the gram-positive bacteria, gram-negative bacteria, protozoan cysts, and fungi.

Description

technical field [0001] The present invention relates to the medical field of photodynamic sterilization therapy and other industrial fields, in particular to a photosensitive drug preparation for photodynamic sterilization and its use, more precisely, the present invention relates to a photosensitive agent, at least one Quaternary ammonium salts and other pharmaceutically acceptable carriers such as viscosity regulators, pH regulators, stabilizers, excipients, etc., are photosensitive pharmaceutical preparations made through appropriate preparation techniques, and their use for photosensitive treatment of the target treatment area During dynamic sterilization, quaternary ammonium salts have a synergistic antimicrobial effect on pathogenic microorganisms such as Gram-positive bacteria, Gram-negative bacteria, yeasts, fungi, and parasitic protists. Background technique [0002] The efficacy of photodynamic therapy in the treatment of malignant tumors has been recognized, and p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K31/14A61K31/722A61P31/04A61P31/10A61P33/00
CPCA61K31/14A61K31/722A61K41/0057A61K2300/00
Inventor 赵亚南
Owner 郑州嘉泰生物科技有限公司