Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Metal(loid) chalcogen nanoparticles as universal binders for medical isotopes

一种金属纳米粒子、纳米粒子的技术，应用在用于传感的纳米技术、纳米技术、纳米技术等方向，达到好活体内稳定性和功效、广泛适用性、系统和/或方法简单的效果

Inactive Publication Date: 2017-05-17
MEMORIAL SLOAN KETTERING CANCER CENT
View PDF7 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional methods in particular remain limited to specific isotopes rather than being a general platform for many substances

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Metal(loid) chalcogen nanoparticles as universal binders for medical isotopes
  • Metal(loid) chalcogen nanoparticles as universal binders for medical isotopes
  • Metal(loid) chalcogen nanoparticles as universal binders for medical isotopes

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0183] Example 1: Synthesis of Labeled Silica Nanoparticles

[0184] Those of skill in the art reading this disclosure will immediately understand that (like) metal chalcogenide nanoparticles can be synthesized by a variety of methods. Without wishing to be bound by a particular synthetic procedure, the silica nanoparticles used in Example 1 were produced via a modified Stober reaction. Briefly, microporous 120 nm silica nanoparticles were synthesized by reacting 1.25 ml tetraethylorthosilicate, 625 μL 28% ammonium hydroxide, and 3.75 ml ultrapure water in 25 ml ethanol under ambient conditions for 50-60 min .

[0185]The hydrodynamic diameters of silica nanoparticles before and after labeling were determined via DLS (Nano-ZS, Malvern, Westborough, MA). The same instrument is used in ultrapure water (>18.2MΩcm at 25°C -1 Nanoparticle surface charge measurements (zeta potential) were performed in Millipore, Milli-Q, Millipore, Billerica, MA. For determination of silica nano...

example 2

[0208] Example 2: Exemplary protocol for the synthesis of chelator-free PET-SE(R)RS nanoparticles

[0209] Synthesis of SERRS nanoparticles

[0210] By adding 1.5 ml of 1 wt% sodium citrate to 200 mL of boiling 0.01 wt% HAuCl 4 Gold nanoparticle cores were synthesized in aqueous solution. Nanoparticle cores were collected by centrifugation (10 min, 4000 g, 4° C.) and dialyzed against 18.2-megohm-cm water (3.5 kDa molecular weight cut-off; Slide-A-Lyzer G2, ThermoFisher Scientific Inc.) ). Improved Stobel Methods Dialyzed gold nanoparticles (approximately 55 nm) were directly coated with dye-intercalated silica without the need for a primer on the surface. Briefly, 1.0 ml of water containing 3.0 nM gold nanoparticles was added to 8.5 ml of ethanol, to which was added 15 ml of DMF containing 25 mM of a resonant dye molecule such as IR-780 perchlorate, 320 ml of tetraethylorthosilicate Ester (TEOS) and 130ml of 28% ammonium hydroxide and allowed to react for 25min. SE(R)...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present disclosure, among other things, provides new technologies for preparation of medical isotope labeled metal(loid) chalcogen nanoparticles for use in medical imaging and / or therapeutic applications. Provided technologies show a number of advantages as compared with previously available options for preparing and utilizing medical isotopes, including, for example, they utilize metal(loid) chalcogen nanoparticles that serve as universal binders (e.g., via covalent or non-covalent (e.g., chelate) bonds) for medical isotopes to provide medical isotope labeled metal(loid) chalcogen nanoparticles. Surprisingly, the same metal(loid) chalcogen nanoparticles may be used to bind (e.g., covalent or non-covalent e.g., chelation) bonding) a wide variety of different useful medical isotopes without the use of traditional chelating agents.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to and benefit of U.S. Provisional Patent Application No. 62 / 030,005, filed July 28, 2014, which is hereby incorporated by reference in its entirety. [0003] governmental support [0004] This invention was made with government support under NIH / NCI K08CA163961 and R01EB014944-01 awarded by the National Institute of Health. The government has certain rights in this invention. Background technique [0005] A wide variety of medical isotopes are used in medical imaging and / or therapeutic applications. There is a continuing need to develop improved techniques utilizing such agents. In particular, there is a need to develop technologies that facilitate the effective use of radioactive or therapeutic medical isotopes, such as radiolabeled nanoparticles. [0006] Traditional methods for radiolabeling of nanoparticles are usually tailored to specific radioisotopes and radiolabeling of na...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K51/12
CPCA61K51/1251B82Y15/00A61P35/00A61K51/025A61K51/1244
Inventor M·A·瓦尔T·谢弗S·哈姆森J·格里姆M·F·基歇尔
Owner MEMORIAL SLOAN KETTERING CANCER CENT
Features
  • Generate Ideas
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com