Antiallergic drug coating composition as well as preparation method and application thereof

A drug coating and anti-allergic technology, which is applied in the direction of drug combination, drug delivery, and pharmaceutical formulations, can solve the problems of short-term drug effect, reduced drug treatment effect, and failure to reach the sinus body, etc., to achieve the effect of improving the therapeutic effect

Active Publication Date: 2017-05-24
ZHEJIANG BARTY MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the occlusion of the tissue, the drug molecules cannot reach the lesion completely, and the therapeutic effect of the drug is greatly reduced.
As mentioned above, sinusitis can accumulate almost all sinuses, and through the above methods, the short-term drug effect is almost limited to the turbinate, and cannot reach the inside of the sinuses, and cannot directly act on the inflamed sinuses

Method used

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  • Antiallergic drug coating composition as well as preparation method and application thereof
  • Antiallergic drug coating composition as well as preparation method and application thereof
  • Antiallergic drug coating composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The composition is composed of 20wt% cetirizine hydrochloride granules and 80wt% sodium alginate (weight average molecular weight is 50000) granules, prepared by the following method:

[0025] (1) Each substance is added into water successively, and dissolved to obtain a solution;

[0026] (2) Vacuum drying at 50-60° C., grinding with a grinder and sieving (80 mesh, 180 μm) to obtain the anti-allergic drug coating composition.

Embodiment 2

[0028] The difference from Example 1 is that the composition consists of 20wt% cetirizine hydrochloride granules and 80wt% sodium alginate (weight average molecular weight: 60000) granules.

Embodiment 3

[0030] The difference from Example 1 is that the composition consists of 20wt% cetirizine hydrochloride granules and 80wt% chitosan (weight average molecular weight 60000, deacetylation degree 90%) granules.

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Abstract

The invention discloses antiallergic drug coating composition. The antiallergic drug coating composition is characterized by comprising antiallergic drug particles and polymer A particles, wherein the polymer A is selected from sodium alginate or chitosan, and the antiallergic drug particles account for 15%-20% of the total mass. The drug composition is applied to the inside of the paranasal sinus (by spraying or brushing) to form a drug coating, drug ingredients in the coating are released slowly, and long-term fixed-point and quantitative administration to the part of lesion can be realized. The invention further provides a preparation method and an application of the composition.

Description

technical field [0001] The invention relates to the technical field of medical device preparation, in particular to a coating composition for antiallergic drugs, a preparation method and application thereof. Background technique [0002] Nasal sinuses, also known as paranasal sinuses, are the general term for the air-containing cavities in the skull (frontal bone, sphenoid bone, maxilla, and ethmoid bone) around the nasal cavity. Resonate with pronunciation. The sinuses are paired left and right, a total of four pairs, called the frontal sinus, maxillary sinus, sphenoid sinus, and ethmoid sinus. [0003] Inflammation of one or more sinuses is called sinusitis, which can affect all sinus bodies. It is a disease with a high incidence in the population and affects the quality of life of patients. Sinusitis can be divided into acute and chronic sinusitis. Acute sinusitis is mostly caused by upper respiratory tract infection, and bacterial and viral infections can be concurren...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/36A61K47/32A61K31/4535A61K31/495A61K31/5415A61P37/08A61P11/02
CPCA61K9/0002A61K9/0043A61K9/146A61K31/4535A61K31/495A61K31/5415A61K47/32A61K47/36
Inventor 季培红王成刘杨陈静何旭玲颜玉强王书琦杨立峰
Owner ZHEJIANG BARTY MEDICAL TECH CO LTD
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