Preparation method for composite scaffold material based on collagen and collagen fibers

Abstract

The invention discloses a preparation method for a composite scaffold material based on collagen and collagen fibers; the preparation method is characterized in that collagen and aggregative-state structural body collagen fibers are mixed organically, functional oxidized polysaccharide and graphene oxide are used for composite synergistic modification of a collagen-collagen fiber composite solution, next, the collagen-collagen fiber composite solution is co-mixed with a certain amount of chitosan and polyvinyl alcohol, and then through 3D printing, microwave drying film formation, electric spraying, sterilization and other processes, the composite scaffold material based on the collagen and the collagen fibers is finally obtained. The material adopts the collagen fibers having a natural collagen structure and having stronger biomimetic property, the microstructure and morphology of the scaffold are biologically designed by using the 3D printing technology, natural active tissues are fully mimicked in the chemical composition and the natural structure, and the obtained scaffold material has the advantages of stable structure, superior physical and chemical properties, and good cell compatibility and biodegradability, also can induce tissue regeneration and repair, and can be used as various types of tissue engineering scaffolds.

Description

technical field [0001] The invention relates to a composite support material based on collagen and collagen fibers, belonging to the field of biomedical material preparation. Background technique [0002] Tissue engineering scaffold is the most basic structure of tissue engineering tissue, which provides a suitable environment for the growth of cells and tissues, and gradually degrades and disappears with the construction of tissues, thus providing new space for tissues and cells. This structure is the place where cells obtain nutrients, gas exchange, waste excretion and growth metabolism, and is the basis for forming new tissues and organs with certain shapes and functions. For decades, living tissue has been produced through a "two-step process". The first step is to design a scaffold for the tissue using some kind of biodegradable material. To fabricate a designed scaffold using traditional methods, researchers model it, sculpt it, or use chemicals to etch a porous shap...

AI Technical Summary

Problems solved by technology

A large number of studies have proved that these technologies have many disadvantages, such as a large amount of highly toxic organic solvents, long manufacturing cycles, labor-intensive processes, inability to completely remove residues in the polymer matrix, poor reproducibility, and irregular pores. The space cannot be fully connected, the structure is too thin, etc.

Furthermore, most of these methods cannot control the shape