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A method for promoting biofermentative synthesis of android quinol

A bio-fermentation and liquid-state fermentation technology, applied in the field of microbial fermentation, can solve the problems of difficult synthesis of Antroquinonol and lack of in-depth research on biosynthetic pathways, and achieve the effect of simple method and short fermentation time

Active Publication Date: 2020-11-24
曹书华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The active product of Antrodia camphorata fermentation, Antroquinonol, has a relatively novel molecular structure, and there is still no in-depth research on its biosynthetic pathway. It is difficult to synthesize Antroquinonol using common liquid fermentation medium components.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The culture medium formula of the present embodiment is:

[0017] Incline medium: potato 200g / L, glucose 20g / L, agar 20g / L.

[0018] Liquid seed medium: glucose 20g / L, soybean powder 4g / L, corn steep liquor powder 2g / L, magnesium sulfate 0.1g / L, potassium dihydrogen phosphate 0.5g / L

[0019] Liquid fermentation basic medium: glucose 30g / L, soybean powder 5g / L, corn steep liquor powder 3g / L, magnesium sulfate 0.1g / L, potassium dihydrogen phosphate 0.5g / L.

[0020] Transfer Antrodia camphorata fungus to a fresh slant, culture at a constant temperature of 30°C for 14 days to obtain fresh Antrodia camphorata slant, wash the spores with a certain amount of sterile water to prepare a spore suspension, and insert the inoculum with a volume ratio of 10% into a In a 500mL Erlenmeyer flask containing 100mL of seed medium, culture at 30°C and 130r / min for 3 days at a constant temperature; then, transfer the seed liquid into a 500mL Erlenmeyer flask containing 100mL of fermentatio...

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Abstract

The invention discloses a method for synthesizing antroquinonol by promoting biological fermentation, belonging to the technical field of microbial fermentation. The method effectively improves the yield of the antroquinonol, produced by carrying out liquid state fermentation on antrodia camphorata, by adding soya bean lecithin or tobacco leaves and mevalonic acid into culture medium within a certain period of culture time.

Description

technical field [0001] The invention relates to a method for promoting biofermentation to synthesize anthroquinol, which belongs to the technical field of microbial fermentation. Background technique [0002] D( Antrodiacamphorata ), also known as Antrodia cinnamomea and Antrodia cinnamomea, is a very rare type of fungus with both edible and medicinal properties unique to Taiwan. Antrodia camphorata fruiting body and mycelia contain more than 70 kinds of physiologically active substances such as polysaccharides, triterpenoids, unsaturated fatty acids, ubiquinones, maleic acid and succinic acid derivatives, etc., which have a wide range of pharmacological activities . [0003] The physiologically active substance Antroquinonol (Antroquinonol) is a new compound extracted and identified from the fruiting bodies of Antrodia camphorata or solid fermentation powder of Antrodia camphorata by using n-hexane in 2007, which belongs to the derivatives of ubiquinones. In 2010, resear...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P7/26C12R1/645
CPCC12P7/26
Inventor 曹书华
Owner 曹书华