Gradient pore diameter filtering membrane and preparation method and application thereof

A technology of filtration membrane and pore size, applied in the direction of filtration accessories, instruments introduced into the body, etc., can solve the problems of filtration effect and general stagnation effect, etc., and achieve the effect of increasing the safety and convenience of use, and the safety and convenience of the infusion process.

Inactive Publication Date: 2017-05-31
NORTHWESTERN POLYTECHNICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The Chinese patent with the application number 201310431919.1 discloses the application of a polyethersulfone microporous film in an automatic liquid stopper. The polyethersulfone microporous film is used as the automatic liquid stopper in the infusion set. The polyethersulfone microporous film It has a strong hydrophilic and asymmetric membrane pore structure, but its filtration effect and liquid stop effect are average, which needs to be further improved and optimized

Method used

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  • Gradient pore diameter filtering membrane and preparation method and application thereof
  • Gradient pore diameter filtering membrane and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] Embodiment 1: Polycaprolactone (PCL) prepares gradient pore size filter membrane

[0031] Select polycaprolactone (PCL) dissolved in hexafluoroisopropanol (HFIP) 8wt% as the spinning solution, rationally design and prepare three-layer gradient pore size filter membrane, prepare the filter membrane after near-field electrospinning, and the moving speed range of the receiving plate 20 ~ 100mm / s, take it off and dry it in vacuum at 60°C. The prepared gradient pore size filter membrane, the upper and lower layers have a pore size of 5-7 μm, the middle layer is 0.5-2 μm, the thickness of the upper and lower layers of the filter membrane is 0.3 mm, the middle layer is 0.4 mm, and the overall thickness is about 1.0 mm. The liquid-stop filter tank forms an automatic liquid-stop device for the actual test of physiological saline infusion.

[0032] After testing, the gradient aperture filter membrane prepared by the polycaprolactone has a good filtering effect on particulates du...

Embodiment 2

[0033] Embodiment 2: Polylactic acid (PLA) prepares gradient aperture filter membrane

[0034] Select polylactic acid (PLA) dissolved in dichloromethane 10wt% as the spinning solution, rationally design and prepare three-layer gradient pore size filter membrane, prepare the filter membrane after near-field electrospinning, the moving speed range of the receiving plate is 50-100mm / s, take After vacuum drying at 60°C, a gradient pore size filter membrane is prepared. The pore size of the upper and lower layers is 6-8 μm, and the middle layer is 0.5-1.5 μm. The thickness of the upper and lower layers of the membrane is 0.25 mm, and the middle layer is 0.6 mm. The overall thickness About 1.1mm, it is installed into the liquid stop filter tank to form an automatic liquid stop device for intravenous infusion of glucose medicine.

[0035] After testing, the gradient pore size filter membrane prepared by the polylactic acid has a good filtering effect on particulates during infusion, ...

Embodiment 3

[0036] Embodiment 3: Polylactic acid-glycolic acid copolymer (PLGA) prepares gradient pore size filter membrane

[0037] Select polylactic acid-glycolic acid copolymer (PLGA) dissolved in 12wt% chloroform as the spinning solution, rationally design and prepare three-layer gradient pore size filter membrane, prepare the filter membrane after near-field electrospinning, and the moving speed range of the receiving plate is 100-200mm / s, take it off and dry it under vacuum at 60°C. The prepared gradient pore size filter membrane, the upper and lower layers have a pore size of 6-8 μm, the middle layer is 0.5-2.0 μm, the thickness of the upper and lower layers of the filter membrane is 0.3 mm, the middle layer is 0.6 mm, and the overall thickness is about 1.2 mm. An automatic liquid stop device is installed in the liquid stop filter tank for intravenous infusion and delivery of glucose medicine solution.

[0038] After testing, the gradient pore size filter membrane prepared by the p...

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Abstract

The invention provides a gradient pore diameter filtering membrane and a preparation method and application thereof. The gradient pore diameter filtering membrane is formed by electrostatic spinning of a high-molecular polymer material. The gradient pore diameter filtering membrane comprises a three-layer structure in close attachment. The outer-side two-layer structure has a pore diameter of 5-10 [mu]m and a thickness of 0.1-0.4 mm; the middle layer structure has a pore diameter of 0.5-5 [mu]m and a thickness of 0.3-0.6 mm, a hollow columnar liquid stopping filter membrane groove is installed between the lower end of a medicine liquid container and a transfusion hose, the inner diameter of the liquid stopping filter membrane groove is larger than that of the transfusion hose, the gradient pore diameter filtering membrane is installed in the liquid stopping filter membrane groove, and the cross section of the liquid stopping filter membrane groove is sealed completely. Flow of medicine liquid in an infusion apparatus is not affected, the medicine liquid can be timely terminated after the transfusion is over, and use safety and convenience of the automatic liquid stopping infusion apparatus are improved, so the whole transfusion process is safer and more convenient.

Description

technical field [0001] The invention relates to a gradient aperture filter membrane. Background technique [0002] In recent years, people's living standards have gradually improved, and the country's investment in medical care has increased year by year. More and more medical consumables with special functions are used in treatment. more widely used. [0003] The defect of the existing intravenous infusion treatment is mainly that the infusion is polluted. The presence of the infusion equipment and the medicine itself and the foreign matter produced during the infusion enter the human body together with the medicine, causing adverse reactions. The pollution is mainly particles, that is, insoluble particulate impurities with a particle size below 50 μm that cannot be observed by the naked eye. After entering the human body, on the one hand, the particles can cause vascular embolism and local tissue necrosis, and vascular blockage and damage can cause edema and inflammation...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M5/165
CPCA61M5/165A61M2005/1657
Inventor 叶雅静柳洋阳周雅青尹大川
Owner NORTHWESTERN POLYTECHNICAL UNIV
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