Method for preparing cube-shaped silver nano box with octreotide acetate as template

An octreotide acetate and silver nanotechnology, applied in the field of materials, can solve the problems of high cost, potential environmental and biological hazards, complex preparation process and the like, and achieve the effects of regular morphology, good binding condition and simple preparation process

Active Publication Date: 2017-05-31
YANSHAN UNIV
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  • Description
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  • Application Information

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Problems solved by technology

However, these methods have disadvantages such as complicated preparation process and high cost, and most of thes...

Method used

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  • Method for preparing cube-shaped silver nano box with octreotide acetate as template
  • Method for preparing cube-shaped silver nano box with octreotide acetate as template
  • Method for preparing cube-shaped silver nano box with octreotide acetate as template

Examples

Experimental program
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Effect test

Embodiment 1

[0022] Dissolve octreotide acetate (Shanghai Taishi Biotechnology Co., Ltd.) in hydrochloric acid (Yongfei Chemical Factory) solution to prepare octreotide acetate solution with a concentration of 0.1mM and a pH value of 3, and then place it in a constant temperature metal bath at 60°C 30min;

[0023] Prepare AgNO at a concentration of 0.9mM 3 (Beijing Beihua Fine Chemicals Co., Ltd.) solution and ascorbic acid (Beijing Baierdi Biotechnology Co., Ltd.) solution with a mass concentration of 3%, they were mixed with a volume ratio of 1:1, and ultrasonic treatment was performed for 30 s, and the ultrasonic power was 90W, to obtain silver colloidal solution;

[0024] Prepare AgNO at a concentration of 7mM 3 (Beijing Beihua Fine Chemicals Co., Ltd.) solution, mixed with the above-mentioned octreotide acetate solution and silver colloid solution at a volume ratio of 1:1:3, placed in a digital display double-layer air bath constant temperature oscillator, at 200rpm., Incubate at 1...

Embodiment 2

[0028] Dissolve octreotide acetate (Shanghai Taishi Biotechnology Co., Ltd.) in hydrochloric acid (Yongfei Chemical Factory) solution to prepare an octreotide acetate solution with a concentration of 0.2mM and a pH value of 2, and then place it in a constant temperature metal bath at 70°C 20min;

[0029] Prepare AgNO at a concentration of 1.1mM 3 (Beijing Beihua Fine Chemicals Co., Ltd.) solution and ascorbic acid (Beijing Baierdi Biotechnology Co., Ltd.) solution with a mass concentration of 2%, mixed with a volume ratio of 1:2, ultrasonically treated for 45s, and the ultrasonic power was 70W. Obtain silver colloidal solution;

[0030] Prepare AgNO at a concentration of 6mM 3 (Beijing Beihua Fine Chemicals Co., Ltd.) solution, mixed with the above-mentioned octreotide acetate solution and silver colloid solution in a volume ratio of 1:1:2, placed in a digital display double-layer air bath constant temperature oscillator, at 150rpm., Incubate at 20°C for 30 hours;

[0031]...

Embodiment 3

[0034] Dissolve octreotide acetate (Shanghai Taishi Biotechnology Co., Ltd.) in hydrochloric acid (Yongfei Chemical Factory) solution to prepare an octreotide acetate solution with a concentration of 0.3mM and a pH value of 1, and place it in a constant temperature metal bath at 90°C for 10 minutes ;

[0035] Prepare AgNO at a concentration of 1.2mM 3 (Beijing Beihua Fine Chemicals Co., Ltd.) solution and ascorbic acid (Beijing Baierdi Biotechnology Co., Ltd.) solution with a mass concentration of 1% were mixed at a volume ratio of 1:3, and ultrasonic treatment was performed for 1 min, and the ultrasonic power was 60W. Obtain silver colloidal solution;

[0036] Prepare AgNO at a concentration of 4mM 3 (Beijing Beihua Fine Chemicals Co., Ltd.) solution, mixed with the above-mentioned octreotide acetate solution and silver colloid solution at a volume ratio of 1:1:1, placed in a digital display double-layer air bath constant temperature oscillator, at 100rpm., Incubate at 30°...

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Abstract

Provided is a method for preparing a cube-shaped silver nano box with octreotide acetate as a template. The method mainly comprises the steps that an octreotide acetate acid solution with the concentration being 0.1 mM to 0.3 mM is used for carrying out constant temperature treatment for 10 min to 30 min at the temperature of 60 DEG C to 90 DEG C; 1-3% ascorbic acid and a 0.9-1.2 mM silver nitrate solution are mixed, treatment is carried out for 30 s to 1 min at ultrasonic waves of 60 W to 90 W, and a colloidal solution of silver is obtained; the octreotide acetate solution, the colloidal solution of silver and the silver nitrate solution are mixed according to the volume ratio of 1:1:(1-3) and placed in an oscillator, and incubation is carried out for 20 h to 50 h at the temperature of 15 DEG C to 25 DEG C; and a sodium borohydride water solution is dropwise added, the molar ratio of the sodium borohydride water solution to silver nitrate is (8-12):1, reacting is carried out at the temperature of 20 DEG C to 30 DEG C till the color of the solution turns into ash black, and the cube-shaped silver nano box is prepared. The preparation process is simple, conditions are mild, cost is low, the morphology is controllable, and the metal load rate is high; and tumor cell heat fusion death can be induced through photothermal conversion under near-infrared light irradiation, and the effect of treating tumors is achieved.

Description

technical field [0001] The invention belongs to the technical field of materials, in particular to a preparation method of nanometer materials. Background technique [0002] Because silver nanomaterials have excellent catalytic, conductive, heat exchange and other properties, they have been widely used in antibacterial materials, catalytic materials, medical materials, etc. Therefore, the research on the preparation methods and characteristics of silver nanomaterials is particularly important. Studies have shown that the properties of metallic nanomaterials mainly depend on their size, morphology, composition, and crystallinity. In principle, the properties of metal nanomaterials can be tuned by controlling these parameters. Among these parameters, morphology control can be considered to provide one of the most efficient ways to tune the properties of metallic nanostructures. [0003] At present, the synthesis methods of nano-silver mainly include chemical reduction method...

Claims

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Application Information

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IPC IPC(8): B22F9/24B22F1/00B82Y30/00B82Y40/00
CPCB82Y30/00B82Y40/00B22F9/24B22F1/0549B22F1/07B22F1/054
Inventor 高大威边可新高发明尹甜牛康刘欢李彦集
Owner YANSHAN UNIV
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