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Method for preparing high-sensitivity pemoline molecular imprinting electrochemical sensor

A molecular imprinting, high-sensitivity technology, applied in electrochemical variables of materials, scientific instruments, instruments, etc., can solve the problems of poor cross-linking rigidity, low sensitivity, improper matching of functional monomers with template molecules and cross-linking agents, etc. , to achieve the effect of easy production, simple equipment and excellent sensitivity

Inactive Publication Date: 2017-05-31
GUANGXI UNIV FOR NATITIES
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Problems solved by technology

The current method is not sensitive due to the inappropriate matching of selected functional monomers with template molecules and cross-linking agents, and the rigidity of cross-linking is also poor.

Method used

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  • Method for preparing high-sensitivity pemoline molecular imprinting electrochemical sensor

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Embodiment 1

[0015] 1. Treatment of glassy carbon electrodes

[0016] Polish the glassy carbon electrode on a polishing cloth with 1.0 μm, 0.3 μm and 0.05 μm alumina powder in sequence, then put it into nitric acid with a volume ratio of 1:1 for 6 minutes, then put it into absolute ethanol for 6 minutes, and finally Ultrasonic cleaning with pure water.

[0017] 2. Preparation of pemoline molecularly imprinted electrochemical sensor

[0018] Use water as a solvent to prepare 15ml of a mixed aqueous solution of 0.2mol / L cobalt (II) sulfate and 0.2mol / L zinc sulfate, and use N,N-dimethylformamide as a solvent to prepare a concentration of 0.05mol / L of 1,4-cyclohexanedicarboxylic acid solution 40ml, then take the mixed aqueous solution of 15ml of cobalt sulfate (II) and zinc sulfate and add it dropwise to the prepared 40ml of 1,4-cyclohexanedicarboxylic acid at a rate of 5 drops / second In the solution, stir vigorously at a speed of 3000 rpm during the dropping process, and then react in a ...

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Abstract

The invention discloses a method for preparing a high-sensitivity pemoline molecular imprinting electrochemical sensor. According to the method, the high-sensitivity pemoline molecular imprinting electrochemical sensor is prepared from pemoline as template molecules, forsythoside as a functional monomer, azodiisobutyronitrile as an initiator, a copper-zinc double-metal organic frame material as a doping agent and acetylshikonin as a cross-linking agent. The analysis method is simple and practical, and defects that a conventional analysis method is complex, expensive in equipment and low in sensitivity can be overcome.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a preparation method of a high-sensitivity pemoline molecularly imprinted electrochemical sensor. Background technique [0002] Pemoline (Pemoline) indications: it is a central sympathomimetic drug. It is used to treat children with ADHD, mild depression and narcolepsy, and it can also be used for atopic dermatitis. However, long-term use of such drugs can cause high fever, dilated pupils, headache, tremor, convulsions, convulsions, hyperreflexia, hallucinations, delirium, confusion, tachycardia in the cardiovascular system, and hypertension; , liver function liver failure. [0003] Methods for the determination of pemoline include high performance liquid chromatography, chromatographic mass spectrometry, etc. However, due to the need for expensive instruments and equipment, these methods have disadvantages such as high cost, long time-consuming, and low sensit...

Claims

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Application Information

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IPC IPC(8): G01N27/30G01N27/48
CPCG01N27/308G01N27/48
Inventor 马祥英陈其锋余会成
Owner GUANGXI UNIV FOR NATITIES
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