Compound xylocaine cream pharmaceutical composition and preparation method thereof
A technology of lidocaine cream and lidocaine, which is applied in the field of compound lidocaine cream pharmaceutical composition and its preparation, can solve the problems of easy moisture absorption and difficult storage, and achieve moistening of the paste, convenient medication, and dispersion uniform effect
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Embodiment 1
[0044] Example 1 Preparation of compound lidocaine cream pharmaceutical composition
[0045] Prescription composition (preparation of 10kg cream):
[0046]
[0047] Preparation:
[0048] (1) Preparation of water phase: Weigh carbomer 974P according to the prescription, and measure purified water according to the preparation of 1.2% carbomer 974P aqueous solution, slowly add carbomer 974P to purified water, and stir for more than 1 hour to dissolve completely. Prepare the water phase;
[0049] (2) Preparation of oil phase: take lidocaine and prilocaine in the main pot according to the prescription, stir and mix uniformly at 40-50 ℃, and melt to a transparent liquid to obtain the eutectic of lidocaine and prilocaine; Polyoxyethylene 40 hydrogenated castor oil in the prescription amount is melted at 60°C and added to the eutectic, and stirred evenly to prepare the oil phase for use;
[0050] (3) Prepare 10% sodium hydroxide solution with purified water according to the prescription amoun...
Embodiment 2
[0059] Example 2 Preparation of compound lidocaine cream pharmaceutical composition
[0060] Prescription composition (preparation of 45kg cream):
[0061]
[0062] Preparation:
[0063] (1) Water phase preparation: slowly add the prescribed amount of Carbomer 940 to 18525g purified water, stir for more than 1 hour to completely dissolve to obtain the water phase;
[0064] (2) Preparation of oil phase: take lidocaine and prilocaine in the main pot according to the prescription, stir and mix uniformly at 40-50 ℃, and melt to a transparent liquid to obtain the eutectic of lidocaine and prilocaine; Polyoxyethylene 80 hydrogenated castor oil in the prescription amount is melted at 60°C and added to the eutectic, and stirred to obtain an oil phase for use;
[0065] (3) Prepare 10% sodium hydroxide solution with purified water according to the prescription amount;
[0066] (4) Emulsification: add the remaining purified water to the oil phase prepared in step (2), set the slow stirring and wal...
Embodiment 3
[0068] Example 3 Preparation of compound lidocaine cream pharmaceutical composition
[0069] Prescription composition (preparation of 10kg cream):
[0070]
[0071] Preparation:
[0072] (1) Preparation of water phase: Weigh carbomer 934 according to the prescription, and measure purified water according to the 0.5% aqueous solution of carbomer 934, add carbomer 934 slowly to purified water, and stir for more than 1 hour to dissolve completely. Prepare the water phase;
[0073] (2) Preparation of oil phase: take lidocaine and prilocaine in the main pot according to the prescription, stir and mix uniformly at 40-50 ℃, and melt to a transparent liquid to obtain the eutectic of lidocaine and prilocaine; Polyoxyethylene 80 hydrogenated castor oil in the prescription amount is melted at 60°C and added to the eutectic, and stirred to obtain an oil phase for use;
[0074] (3) Prepare 5% sodium hydroxide solution with purified water according to the prescription amount;
[0075] (4) Emulsifica...
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