Method for extracting neohesperidin from immature bitter orange and comprehensively utilizing immature bitter orange

A technology of neohesperidin and hesperidin, which is applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., can solve the problems of low price of neohesperidin, high cost of raw material extraction, waste of resources, and the like, Achieve good social benefits, reduce purification steps, and prevent pollution

Active Publication Date: 2017-06-09
YONGZHOU YIDONG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the price of neohesperidin is low at present, and the cost of raw materials and extraction is high. It is not worth the loss for manufacturers to rely on one item alone, and it also causes waste and pollution of resources. There are few reports on the effective isolation and purification of dermatosin

Method used

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  • Method for extracting neohesperidin from immature bitter orange and comprehensively utilizing immature bitter orange
  • Method for extracting neohesperidin from immature bitter orange and comprehensively utilizing immature bitter orange

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] 1) Get 500 kilograms of Fructus Fructus Aurantii (reverse high performance liquid chromatography analysis naringin 7.72%, hesperidin 0.93%, neohesperidin 8.61%, spectrophotometry pectin content 10.3%), broken to 100% 14 mesh sieve;

[0104] 2) Warm water ultrasonic leaching: put 500 kg of citrus aurantium powder into the extraction tank for the first extraction, add 5000 kg of purified water to the extraction tank, heat to 60 degrees to keep it stable, turn on ultrasonic vibration, and extract for 6 hours, the second time Add 2500 kg of purified water for extraction, heat to 60 degrees, extract for 4 hours, combine the first and second extraction solutions to obtain 6992 kilograms of extraction solution and 991 kilograms of filter residue;

[0105] 3) Separation and purification of combined extracts:

[0106] a) Concentration: vacuum-concentrate the combined extraction solution at a vacuum degree of negative pressure -0.08--0.09MPA, the temperature does not exceed 60 d...

Embodiment 2

[0117] 1) Get 500 kilograms of Citrus aurantium (reversed high performance liquid chromatography analysis of naringin 7.64%, hesperidin 0.88%, neohesperidin 8.33%, spectrophotometry pectin content 10.1%), broken to 100% 14 mesh sieve;

[0118] 2) Warm water ultrasonic leaching: put 500 kg of citrus aurantium powder into the extraction tank for the first extraction, add 5000 kg of purified water to the extraction tank, heat to 60 degrees to keep it stable, turn on ultrasonic vibration, and extract for 6 hours, the second time Add 2500 kilograms of purified water for extraction, heat to 60 degrees, extract for 4 hours, combine the first and second extraction solutions to obtain 7039 kilograms of extraction solution and 951 kilograms of filter residue;

[0119] 3) Separation and purification of combined extracts:

[0120] a) Concentration: Concentrate the combined extraction solution in vacuum at a vacuum degree of negative pressure -0.08--0.09MPA, the temperature does not excee...

Embodiment 3

[0131] 1) Get 500 kilograms of Citrus aurantium (reversed high performance liquid chromatography analysis of naringin 7.81%, hesperidin 0.86%, neohesperidin 8.72%, spectrophotometry pectin content 9.7%), broken to 100% 14 mesh sieve;

[0132] 2) Warm water ultrasonic leaching: put 500 kg of citrus aurantium powder into the extraction tank for the first extraction, add 5000 kg of purified water to the extraction tank, heat to 60 degrees to keep it stable, turn on ultrasonic vibration, and extract for 6 hours, the second time Add 2,500 kg of purified water for extraction, heat to 60°C, extract for 4 hours, combine the first and second extracts to obtain 7,013 kg of extract, and 980 kg of filter residue;

[0133] 3) Separation and purification of combined extracts:

[0134] a) Concentration: Concentrate the combined extraction solution in vacuum at a vacuum degree of negative pressure -0.08--0.09MPA, the temperature does not exceed 60 degrees, and concentrate to a specific gravi...

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Abstract

The invention provides a method for extracting neohesperidin from immature bitter orange and comprehensively utilizing immature bitter orange. The method for comprehensive utilization comprises the following steps: 1) crushing and sieving immature bitter orange; 2) leaching the sieved substance with water at temperature of 55-60 DEG C, and collecting the leachate and filter residue respectively; and 3) purifying the filter residue to obtain hesperidin; and/or separating the leachate to obtain one or more of pectin powder, naringin and neohesperidin. In the method provided by the invention, the immature bitter orange is utilized to the greatest extent; the method mainly adopts warm water for extraction and a little alcohol for separation and purification, and thus the use of organic solvent is minimized; and moreover, the technology is simple and effective and has a wide application value.

Description

technical field [0001] The invention relates to the field of separation and purification of active ingredients of traditional Chinese medicines, and more specifically relates to a method for extracting neohesperidin from Fructus Aurantium and comprehensively utilizing Fructus Fructus Aurantii. Background technique [0002] Citrus aurantium is the dried young fruit of the sour orange or sweet orange variety of the citrus genus of Rutaceae. It tastes bitter and is pungent and cold in nature. , Fullness of abdominal distension, chest knot, proctoptosis, gastroptosis effect. Modern medical research shows that the hesperidin in the extract of Citrus aurantium has the effect of regulating the blood pressure of the cardiovascular system. Hemagglutination, anti-thrombosis, anti-cancer, anti-fungal, anti-inflammatory and other effects. [0003] Citrus aurantium contains 10-15% pectin, 7-8% naringin, about 1% hesperidin, about 8% neohesperidin, about 25% total flavonoid content, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/06C07H17/07C07H1/08
Inventor 张宝堂张国雄
Owner YONGZHOU YIDONG BIOTECH
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