A kind of preparation method of drug sustained-release film

A slow-release film and drug technology, used in medical science, bandages, absorbent pads, etc., can solve the problems of unfavorable and comfortable dressings, insufficient hygroscopicity, and low elongation at break, and achieve excellent biomechanics and moisture absorption properties. Effect

Inactive Publication Date: 2019-10-11
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, silk fibroin itself is not a perfect biological material. For example, it has insufficient hygroscopicity and is easily soluble in wound exudate; the elongation at break is small, which is not conducive to being used as a comfortable dressing

Method used

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  • A kind of preparation method of drug sustained-release film
  • A kind of preparation method of drug sustained-release film
  • A kind of preparation method of drug sustained-release film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A kind of preparation method of drug sustained-release membrane, according to the following steps:

[0027] (1) Preparation of regenerated silk fibroin solution:

[0028] Cut high-quality silkworm cocoons into spiral shapes, degummed and dried, then dialyzed, centrifuged, and filtered to obtain a certain concentration of regenerated silk fibroin, and set aside at 4 °C;

[0029] (2) Preparation of sodium alginate solution:

[0030] Prepare 0.8% sodium alginate solution with distilled water, stir for 10 h, and set aside at 4 °C;

[0031] (3) Preparation of drug sustained release film:

[0032] Table 1 Addition amount of sodium alginate, glycerol and glutaraldehyde

[0033]

[0034] Mix silk fibroin with 0.8% sodium alginate at 25 °C, stir at 180 rpm for 25 min; add 75 % glycerol to a volume ratio of 2.0%, at 25 °C, stir at 180 rpm for 15 min, adjust with 0.1 M HCl After the pH reached 6.8, glutaraldehyde was added, and the final volume ratio was shown in Table 1. S...

Embodiment 2

[0047] A kind of preparation method of drug sustained-release membrane, according to the following steps:

[0048] (1) Preparation of regenerated silk fibroin solution:

[0049] Cut high-quality silkworm cocoons into spiral shapes, degummed and dried, then dialyzed, centrifuged, and filtered to obtain a certain concentration of regenerated silk fibroin, and set aside at 4 °C;

[0050] (2) Preparation of sodium alginate solution:

[0051] Sodium alginate solutions of different concentrations were prepared with distilled water, stirred for 10 h, and set aside at 4 °C;

[0052] (3) Preparation of drug sustained release film:

[0053] Table 2 Addition amount of sodium alginate, glycerol and glutaraldehyde

[0054]

[0055] Mix silk fibroin with 0.8% sodium alginate at 180 rpm for 25 minutes; add 75% glycerin to the final volume ratio in Table 2, stir for 15 minutes, adjust the pH to 7.4, and then add glutaraldehyde. 4.0%, stirred for 40 minutes, continued to add the model d...

Embodiment 3

[0063] A kind of preparation method of drug sustained-release membrane, according to the following steps:

[0064] (1) Preparation of regenerated silk fibroin solution:

[0065] Cut high-quality silkworm cocoons into spiral shapes, degummed and dried, then dialyzed, centrifuged, and filtered to obtain a certain concentration of regenerated silk fibroin, and set aside at 4 °C;

[0066] (2) Preparation of sodium alginate solution:

[0067] Sodium alginate solutions of different concentrations were prepared with distilled water, stirred for 10 h, and set aside at 4 °C;

[0068] (3) Preparation of drug sustained release film:

[0069] Table 3 Addition amount of sodium alginate, glycerol and glutaraldehyde

[0070]

[0071] Mix silk fibroin with 0.8% sodium alginate at 180 rpm and stir for 25 minutes; add 75% glycerin to a volume ratio of 2.0%, stir for 15 minutes, adjust the pH to 7.4 and add glutaraldehyde, the final volume ratio is Table 1, stir for more than 2 hours, con...

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Abstract

The invention provides a medicine sustained-release diaphragm and a preparation method thereof. SF and SA are used as materials, and GA and Gly are added, wherein the concentration of silk fibroin is 1 to 4 percent (mass-volume percent), the content of the SA is 40 to 50 percent of the mass of fibroin, the addition amount of the GA is 1 to 8 percent of total volume, and the addition amount of 75 percent Gly is 1.25 to 2.0 percent of the total volume. Sustained-release dressing obtained in the invention is a diaphragm with uniform thickness, and the thickness is about 0.18mm; the medicine sustained-release diaphragm has a controlled sustained-release effect; in addition, a medicine release mechanism belongs to a Fickian model mechanism. The sustained-release diaphragm prepared with the preparation method provided by the invention has excellent biomechanical properties, moisture absorbing and retaining properties and the like. The sustained-release diaphragm provided by the invention has the advantages of perfect sustained-release model, comfortableness, tensile strength and moisture absorbing and retaining properties, and can respectively meet requirements of a comfortable sustained-release diaphragm, a moisture and retaining sustained-release diaphragm and a comfortable moisture and retaining sustained-release diaphragm; the geometrical size of the medicine sustained-release diaphragm can be changed according to clinical demands.

Description

technical field [0001] The invention relates to the technical fields of biological tissue engineering and biological materials, in particular to a preparation method of a drug slow-release wound dressing film. Background technique [0002] Natural silk is composed of silk fibroin (SF) and sericin. Because sericin is immunogenic, and silk fibroin has good biocompatibility, certain mechanical properties and the function of promoting wound healing, so this The invention is based on silk fibroin. [0003] Silk fibroin is widely used in the research of biomaterials, such as skin tissue and wound dressings. However, silk fibroin itself is not a perfect biological material. For example, it has insufficient hygroscopicity and is easily soluble in wound exudate; the elongation at break is small, which is not conducive to being used as a comfortable dressing. Therefore, under normal circumstances, silk fibroin needs to be compounded with other materials to prepare composite material...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/44A61L15/42A61L15/32A61L15/28C08J3/24C08J5/18C08L89/00C08L5/04C08K5/053C08K5/07
Inventor 朱勇高保东徐水钟红荣吴婷芳
Owner SOUTHWEST UNIV
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