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Uses of matrine derivatives in treatment of diabetes mellitus

A technology for diabetes and diabetic nephropathy is applied in the field of use of matrine derivatives in the treatment of diabetes, and can solve problems such as flatulence and the like

Active Publication Date: 2017-06-20
MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Alpha-glucosidase inhibitors may have side effects such as flatulence

Method used

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  • Uses of matrine derivatives in treatment of diabetes mellitus
  • Uses of matrine derivatives in treatment of diabetes mellitus
  • Uses of matrine derivatives in treatment of diabetes mellitus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] Example 1 In vitro HepG2 cell line / L6 cell line / 3T3-L1 cell line sugar consumption and insulin-stimulated sugar consumption experiment

[0097] 1.1 The experimental method is as follows:

[0098] ① Cell culture: HepG2 cells were cultured with 10% FBS+DMEM medium at 37°C, 5% CO 2 Cell culture incubator.

[0099] L6 cells were cultured with 10% FBS+DMEM medium at 37°C, 5% CO 2 The cells were cultured in an incubator, and after the L6 cells were inoculated on the culture plate, after the cell density grew to 80%-90%, continue to induce differentiation with 10% FBS+DMEM medium for 5-7 days.

[0100] 3T3-L1 cells were cultured in 10% FBS+DMEM high glucose at 37°C, 5% CO 2 Cell culture incubator for growth culture. Then place at 37°C, 5% CO 2 The cell incubator was used to induce differentiation culture, and the induction differentiation medium was: 10% FBS+DMEM high-glucose medium, which added 1 μM dexamethasone, 0.5mM 3-isobutyl-1-methylxanthine (IBMX) and 1 μg / ml ins...

Embodiment 2

[0111] Example 2 The pharmacological effect experiment of reducing fasting blood sugar, increasing insulin sensitivity and treating diabetic nephropathy in type 2 diabetic mice

[0112] 2.1 Experimental method

[0113] ① Animal experiments: 8 10-week-old male C57BL / 6J mice, 63 10-week-old male KK / upj-Ay / J mice, among them: C57BL / 6J mice were given maintenance feed, KK / upj-Ay / J Mice were given high-fat and high-sugar diet, and fasting blood glucose was measured after two weeks of feeding, and they were randomly divided into groups. C57BL / 6J mice were used as the normal control group, and KK / upj-Ay / J mice were divided into 5 groups, with 9 mice in each group, of which 1 group was the model control group, and 4 groups were the treatment groups, and the dosages were DB- 1 50mg / kg, DB-1 100mg / kg, BBR 100mg / kg, RZG 5mg / kg.

[0114] The formula of high-fat and high-sugar feed is: protein 16.46%, fat 45.65%, carbohydrate 37.89%.

[0115] ②Measurement of fasting blood glucose: the b...

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PUM

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Abstract

The invention relates to uses of compounds shown as a general formula I, stereisomers thereof or medicinal salts of the compounds in preparation of medicines used for treating diabetes mellitus, or in preparation of medicines for preventing or treating diabetic complications, or in preparation of medicines adopted as euglycemic agents.

Description

technical field [0001] The present invention relates to a new use of matrine derivatives, in particular to the use of matrine derivatives as insulin sensitizers, and to the use of matrine derivatives in the preparation of medicines for treating or preventing diabetes or diabetic complications use. Background technique [0002] Diabetes mellitus (diabetes mellitus) is a group of metabolic diseases characterized by hyperglycemia, divided into type 1 and type 2 diabetes. Long-term high blood sugar, damage to large blood vessels and microvessels and endanger the heart, brain, kidney, peripheral nerves, eyes, feet, etc., will cause a series of complications such as diabetic nephropathy, diabetic eye disease, diabetic cardiovascular complications, diabetic neuropathy, etc. . Once complications occur, drug treatment is difficult to reverse, so it is emphasized to prevent diabetic complications as early as possible. [0003] Drugs currently used to treat diabetes mainly include i...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61P3/10A61P5/50A61P13/12A61P27/02A61P25/28
CPCA61K31/4375
Inventor 宋丹青蒋建东唐胜孔维佳汪燕翔王灿李迎红李玉环张靖浦
Owner MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
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