Adipose tissue targeting polypeptide, preparation method and application thereof

Abstract

The invention relates to the field of protein polypeptides, and in particular relates to an adipose tissue targeting polypeptide as well as a preparation method and application thereof. The adipose tissue targeting polypeptide comprises a cell targeting polypeptide peptide fragment, a cell apoptosis polypeptide peptide fragment and a bridge chain for connecting the cell targeting polypeptide peptide fragment and the cell apoptosis polypeptide peptide fragment. The adipose tissue targeting polypeptide can specifically induce adipocyte apoptosis, so that the effect of reducing fat and losing weight is achieved. Moreover, due to the targeting action mechanism contained in the molecules, the common adverse reactions of existing weight-losing medicines can be avoided, and compared with the existing weight-reducing medicines, the adipose tissue targeting polypeptide has a more direct curative effect and less side effects.

Description

technical field

[0001] The invention relates to the field of protein polypeptides, in particular to a class of adipose tissue-targeting polypeptides and a preparation method and application thereof. Background technique

[0002] Obesity, as a common chronic endocrine and metabolic disease, has an increasing incidence year by year and has become a global public health problem. When the human body eats more calories than it consumes, it will be stored in the body in the form of fat, and more than 20% of the normal body weight is obesity. Obesity can occur at any age, but it is more common in those after the age of 40, and the incidence rate is higher in women. Obesity is divided into two types: one is simple obesity, the main manifestation of which is obesity, without obvious changes in the functions of the nervous system and endocrine system, but accompanied by metabolic regulation disorders, this type of obesity is the most common. The second is secondary obesity, often se...

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