Method for preparing acrylic resin coated nano-drug by solid wall fiber pipe bundle crystallizer

Abstract

The invention provides a method for preparing an acrylic resin coated nano-drug by a solid wall fiber pipe bundle crystallizer and relates to nano-drug preparation. A water bath device, a dissolving drug bottle, two peristaltic pumps, the fiber pipe bundle crystallizer, a vacuum filtration system and a refrigerator are arranged; the dissolving drug bottle is arranged in the water bath device, an inner pipe and an outer pipe are arranged on the fiber pipe bundle crystallizer, the dissolving drug bottle is connected with an inlet of the first peristaltic pump, an outlet of the first peristaltic pump is connected with an inlet of the inner pipe of the fiber pipe bundle crystallizer, an outlet of the inner pipe of the fiber pipe bundle crystallizer is connected with the vacuum filtration system, an outlet of the outer pipe of the fiber pipe bundle crystallizer is connected with an inlet of the second peristaltic pump, an outlet of the second peristaltic pump is connected with an inlet of the outer pipe of the fiber pipe bundle crystallizer, and the inner pipe of the fiber pipe bundle crystallizer is formed by micron size hollow solid wall fiber pipe bundles. The method comprises the steps of preparation of the fiber pipe bundle crystallizer: single bundles of micron size hollow solid wall fiber pipe bundles are cut and put into a sleeve, and the fiber pipe bundle crystallizer is formed; preparation of the nano-drug and coating of acrylic resin; and postprocessing.

Description

technical field [0001] The invention relates to the preparation of nano-medicine, in particular to a method for controlling the preparation of nano-medicine coated with acrylic resin by using a micron-scale hollow solid-wall fiber tube bundle crystallizer. Background technique [0002] In recent years, with the continuous development of nanotechnology, the unique properties of nanomedicine preparations developed based on nanotechnology have gradually been understood by researchers. However, it is difficult to directly use nanomedicine crystals for various reasons. In actual treatment [1]. For example, traditional water-repellent nano-medicines are easily recognized and engulfed by macrophages in the immune system in the body and become ineffective. Studies have found that the use of degradable polymers (such as PLGA, PEG, etc.) to coat nanoparticles made of polymer nanoparticles drug-loaded particles has many advantages: improve drug effectiveness, control release time, pro...

AI Technical Summary

Problems solved by technology

However, these coating methods have some disadvantages

The O / W-based nanoemulsion method is prone to soft agglomeration in the solution due to the unique properties of nanoparticles (high specific surface energy, strong van der Waals force) during the preparation process, and the produced polymer coats multiple nanoparticles and The resulting hard agglomerates cannot be separated; supercritical CO 2 The large-scale production of drugs is limited due to the low solubility of polymers or drug particles; vapor deposition coating method requires high energy consumption conditions such as high temperature; spray drying technology requires high temperature conditions, and has limitations on the size of prepared nanoparticles, which is very It is difficult to prepare particles smaller than 10nm; most of the preparation methods at this stage are batch production (batch process), resulting in low production efficiency and uneven quality of each batch, making it difficult to effectively control in practical applications

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