Method for preparing active pharmaceutical ingredient of magnesium aspartate hydrochloride

A technology of magnesium aspartate hydrochloride and aspartic acid, which is applied in the field of preparation of magnesium aspartate hydrochloride raw materials, can solve problems such as unseen research and production reports, and achieve high product yield and simple process , good stability

Inactive Publication Date: 2017-07-04
LIAONING YAOLIAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The raw material of magnesium aspartate hydrochloride is not imported in China, and there is no report on the research and production of this product by domestic manufacturers and scientific research units

Method used

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  • Method for preparing active pharmaceutical ingredient of magnesium aspartate hydrochloride
  • Method for preparing active pharmaceutical ingredient of magnesium aspartate hydrochloride
  • Method for preparing active pharmaceutical ingredient of magnesium aspartate hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026]

[0027]

[0028] Step (a) Add the prescribed amount of purified water into the liquid mixing tank, heat at 50-60°C, add the weighed magnesium oxide under stirring, add aspartic acid in batches while stirring, and continue stirring until the solution is completed clarify;

[0029] Step (b) Suction filter the reaction liquid while it is hot, send it to a multifunctional vacuum dryer, concentrate the filtrate under reduced pressure, remove 30L of water, let the remaining liquid cool down to room temperature naturally, precipitate a large amount of white solid, and centrifuge;

[0030] Step (c) drying at 50-70°C for 4-7 hours to obtain 36.18 kg of solid magnesium aspartate;

[0031] Step (d) Add 22L of purified water into the ceramic liquid mixing tank, add concentrated hydrochloric acid, and stir well to obtain a hydrochloric acid solution. In the reaction tank, add the prescribed amount of magnesium aspartate and purified water, heat at 40°C, stir for 20 minutes, ...

Embodiment 2

[0036]

[0037]

[0038] Step (a) Add the prescribed amount of purified water into the liquid mixing tank, heat at 50-60°C, add the weighed magnesium oxide under stirring, add aspartic acid in batches while stirring, and continue stirring until the solution is completed clarify;

[0039] Step (b) Suction filter the reaction liquid while it is hot, send it to a multifunctional vacuum dryer, concentrate the filtrate under reduced pressure, remove 30L of water, let the remaining liquid cool down to room temperature naturally, precipitate a large amount of white solid, and centrifuge;

[0040] Step (c) drying at 50-70°C for 4-7 hours to obtain 36.85 kg of solid magnesium aspartate;

[0041] Step (d) Add 22L of purified water into the ceramic liquid mixing tank, add concentrated hydrochloric acid, and stir well to obtain a hydrochloric acid solution. In the reaction tank, add the prescribed amount of magnesium aspartate and purified water, heat at 40°C, stir for 20 minutes, ...

Embodiment 3

[0046]

[0047]

[0048] Step (a) Add the prescribed amount of purified water into the liquid mixing tank, heat at 50-60°C, add the weighed magnesium hydroxide while stirring, add aspartic acid in batches while stirring, and continue stirring until the addition is complete. The solution is clear;

[0049] Step (b) Suction filter the reaction liquid while it is hot, send it to a multifunctional vacuum dryer, concentrate the filtrate under reduced pressure, remove 30L of water, let the remaining liquid cool down to room temperature naturally, precipitate a large amount of white solid, and centrifuge;

[0050] Step (c) drying at 50-70°C for 4-7 hours to obtain 36.78 kg of solid magnesium aspartate;

[0051] Step (d) Add 22L of purified water into the ceramic liquid mixing tank, add concentrated hydrochloric acid, and stir well to obtain a hydrochloric acid solution. In the reaction tank, add the prescribed amount of magnesium aspartate and purified water, heat at 40°C, stir ...

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PUM

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Abstract

The invention discloses a method for preparing an active pharmaceutical ingredient of magnesium aspartate hydrochloride. The method comprises the following specific steps: (a) adding a formula specified volume of purified water into a solution preparation tank, carrying out heating, adding weighed magnesium oxide into the tank with stirring, adding aspartic acid into the tank in batches with stirring, and continuing to stir until the solution is clarified after adding is completed; (b) carrying out suction filtration on the reaction solution while the reaction solution is hot, carrying out depressurized concentration on filtrate so as to remove 1/3 to 1/2 of water, naturally cooling remaining liquid to room temperature so as to precipitate a large amount of white solids, and carrying out centrifugation; (c) carrying out drying, so as to obtain magnesium aspartate solids; (d) adding a specified amount magnesium aspartate and a specified volume of water into a reactor, carrying out heating with the temperature of 40 DEG C, carrying out stirring for 20 minutes, adding a hydrochloric solution into the reactor in batches, and continuing to stir until the reaction solution is clarified; (e) adding medicinal charcoal (0.1% W/V), and carrying out stirring with heating; (f) filtering medicated liquid through a decarbonization filter and a 0.45-microgram filter; and (g) carrying out spray drying, carrying out discharging, carrying out crushing, and carrying out subpackaging.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, and in particular relates to a preparation method of magnesium aspartate hydrochloride crude drug. Background technique [0002] Magnesium ion (Mg++) is a divalent cation and an important element necessary for the human body. It participates in the reactions of more than 300 enzymes and various energy metabolisms in the body. The formation of bones, cells and various membranes is inseparable from the participation of magnesium. Mg++ is the most abundant cation in cells except potassium ions (K+). The total content in the body is about 24g, mainly distributed in bones, muscles and soft tissues. The magnesium in the blood is less than 1%, but the dynamics of magnesium in the body can be understood through its changes. The plasma magnesium concentration of normal people is generally 0.79-1.05mmol / L. Low blood magnesium is caused by insufficient intake, malabsorption and excessive excretion by the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C227/18C07C229/24
CPCC07C227/18C07C229/24
Inventor 于航齐丹
Owner LIAONING YAOLIAN PHARMA
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