Aescin A liposome gel and a preparing method thereof

A technology of liposome gel and aescin, which is applied in liposome delivery, liquid delivery, pharmaceutical formulations, etc., can solve the problems of poor transdermal absorption effect and large skin irritation, and achieve good transdermal absorption effect , reduce incidence, good anti-inflammatory effect

Inactive Publication Date: 2017-07-14
WUHAN AIMIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a liposome gel with aescin A as an active ingredient and a preparation method thereof for the problems of poor transdermal absorption effect and large skin irritation of the existing sodium aescinate external preparations

Method used

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  • Aescin A liposome gel and a preparing method thereof
  • Aescin A liposome gel and a preparing method thereof
  • Aescin A liposome gel and a preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Raw material prescription:

[0022]

[0023] Preparation Process:

[0024] 1) Preparation of liposomes: Take 5g of aescin A, 20g of soybean lecithin and 5g of cholesterol, add 50g of absolute ethanol, stir at 60°C to dissolve, inject the resulting ethanol solution into the liposome at a speed of 15ml / min through a peristaltic pump 250g of purified water at a constant temperature of 60°C was stirred for 30 minutes to make a liposome suspension; then the liposome suspension was placed in a liposome extruder and passed through PC filters with a pore size of 200nm and 100nm in sequence. The membranes were extruded 4 times each to obtain 285 g of the extruded solution; finally, the method of membrane dialysis was used to dilute the extruded solution by adding 200 g of purified water, and then dialyzed 3 times to remove the ethanol in the extruded solution to obtain aescin A liposome 420g;

[0025] The encapsulation efficiency and particle size of the liposomes were dete...

Embodiment 2

[0030] Raw material prescription:

[0031]

[0032] Preparation Process:

[0033] 1) Preparation of liposomes: Take 3g of aescin A, 25g of soybean lecithin and 10g of cholesterol, add 100g of absolute ethanol, stir at 60°C to dissolve, and inject the resulting ethanol solution into the liposome at a speed of 25ml / min through a peristaltic pump 300g of purified water at constant temperature to 60°C was stirred for 30 minutes to make a liposome suspension; then the liposome suspension was placed in a liposome extruder, and passed through PC filters with a pore size of 200nm and 100nm in sequence. Each membrane was extruded 4 times to obtain 350 g of extruded liquid; finally, membrane dialysis was used to dilute the extruded liquid with 300 g of purified water, and then dialyzed 3 times to remove ethanol in the extruded liquid to obtain aescin A liposome 490g;

[0034] The encapsulation efficiency and particle size of the liposomes were detected according to the literature m...

Embodiment 3

[0039] Raw material prescription:

[0040]

[0041] Preparation Process:

[0042] 1) Preparation of liposomes: Take 8g of aescin A, 15g of soybean lecithin and 4g of cholesterol, add 30g of absolute ethanol, stir at 60°C to dissolve, inject the obtained ethanol solution into the liposome at a speed of 5ml / min through a peristaltic pump 150g of purified water at constant temperature to 60°C was stirred for 30 minutes to make a liposome suspension; then the liposome suspension was placed in a liposome extruder and passed through PC filters with a pore size of 200nm and 100nm in sequence. The membranes were extruded 4 times each to obtain 175 g of the extruded solution; finally, the method of membrane dialysis was used to dilute the extruded solution with 150 g of purified water, and then dialyzed 3 times to remove the ethanol in the extruded solution to obtain aescin A liposome 290g;

[0043] The encapsulation efficiency and particle size of the liposomes were detected acco...

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Abstract

Aescin A liposome gel is disclosed. The aescin A liposome gel includes aescin A, soybean phospholipid, cholesterol, carbomer, triethanolamine, EDTA.2Na, menthol, and the like. A preparing method of the aescin A liposome gel is also disclosed and includes a first step of preparing liposome and a second step of preparing the liposome gel. Compared with common gel agents, the liposome gel has better transdermal absorption effects, has a controlled release function, and can be slowly released at a certain speed, thus forming a constant plasma concentration of a medicine in skin and prolonging the treatment time of a medicine. The aescin A liposome gel also can reduce the occurrence rate of skin irritative reactions.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a escin A liposome gel and a preparation method thereof. Background technique [0002] Aescin, also known as aescinic acid, is a general term for total saponins, β-aescin or isoaescin, etc. extracted from the seeds of Aesculus in the family Aescinaceae, belonging to triterpenoid saponins. The water solubility of aescin is poor. In order to increase its solubility, it is often made into sodium salt. Studies have shown that the components with higher content in sodium aescin are aescin A, B, C, and D. Sodium aescinate can reduce the increase of pathological capillary permeability, increase venous tension, reduce the exudation of inflammatory substances, have anti-inflammation, detumescence, pain relief, improve blood circulation, and promote the recovery of acute blunt soft tissue injury. [0003] Oral bioavailability of sodium aescinate is not high, and injection is more irrit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K9/127A61K31/704A61K47/32A61K47/18A61K47/10A61P29/00
CPCA61K9/0002A61K9/0014A61K9/06A61K9/127A61K31/704A61K47/10A61K47/18A61K47/183A61K47/32
Inventor 石召华关小羽李群叶利春张晓存杜文杰
Owner WUHAN AIMIN PHARMA
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