Nano emulsion and preparation method by phase inversion temperature process

A nano-emulsion and emulsifier technology, applied in the chemical industry, can solve the problems of equipment limitation and difficult realization, and achieve the effects of easy realization, low production equipment requirements and production cost saving.

Inactive Publication Date: 2017-07-21
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the preparation of nanoemulsions mainly relies on the high-energy emulsification method, but due to equipment limitations and energy consumption issues, the high-energy emulsification method is difficult to achieve in the actual production process

Method used

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  • Nano emulsion and preparation method by phase inversion temperature process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A nanoemulsion prepared by a phase transition temperature method, calculated by weight percentage, its raw material composition and content are as follows:

[0028] High HLB emulsifier15％ Low HLB emulsifier5％ Solid grease5％ Liquid grease25％ Polyol10％ Deionized water to 100%

[0029] The high HLB emulsifier is steareth-21, cosmetics and products provided by Croda (UK);

[0030] The low HLB emulsifier is steareth-2, cosmetics and products provided by Croda (UK);

[0031] The solid oil is pentaerythritol distearate, cosmetics and products provided by Lubrizol Corporation (USA);

[0032] The mixture of the liquid oil myristyl myristate and cetearyl isononanoate is an industrial grade product provided by BASF (Germany);

[0033] The polyol is pentanediol, an industrial grade product provided by Sinopharm Chemical Reagent Co., Ltd.;

[0034] The above-mentioned method for preparing nanoemulsion by a phase transition temperature method specifically includes the following steps: ...

Embodiment 2

[0042] A nanoemulsion prepared by a phase transition temperature method, calculated by weight percentage, its raw material composition and content are as follows:

[0043] High HLB emulsifier12％ Low HLB emulsifier3％ Solid grease15％ Liquid grease15％ Polyol8％ Deionized water to 100%

[0044] The high HLB emulsifier is Tween-80, an industrial grade product provided by Sinopharm Chemical Reagent Co., Ltd.;

[0045] The low HLB value emulsifier is Ipan-80, an industrial grade product provided by Sinopharm Chemical Reagent Co., Ltd.;

[0046] The solid oil is a mixture of monoglyceride and behenyl alcohol, a cosmetic grade product provided by BASF (Germany);

[0047] The mixture of the liquid oil myristyl myristate and caprylic capric triglyceride is an industrial grade product provided by BASF (Germany);

[0048] The polyol is propylene glycol, an industrial grade product provided by Sinopharm Chemical Reagent Co., Ltd.;

[0049] The above-mentioned method for preparing nanoemulsion ...

Embodiment 3

[0057] A nanoemulsion prepared by a phase transition temperature method, calculated by weight percentage, its raw material composition and content are as follows:

[0058] High HLB emulsifier9％ Low HLB emulsifier1％ Solid grease10％ Liquid grease25％ Polyol15％ Deionized water to 100%

[0059] The high HLB emulsifier is ceteareth-20, a cosmetic-grade product provided by BASF (Germany);

[0060] The low HLB emulsifier is ceteareth-12, a cosmetic grade product provided by BASF (Germany);

[0061] The solid oil is a mixture of pentaerythritol tetrastearate and monoglyceride. Among them, pentaerythritol tetrastearate is a cosmetic-grade product provided by Lubrizol (USA), and monoglyceride is a BASF company (Germany). ) Cosmetic-grade products provided;

[0062] The liquid oil PPG-15 stearyl ether and 26# white oil is a mixture, wherein PPG-15 stearyl ether is a cosmetic-grade product provided by Degussa Company, and 26# white oil is Shanghai Daoxin Trading Co., Ltd. Cosmetic-grade ...

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Abstract

The invention relates to a nano emulsion, which comprises, by weight percentage, 1-15% of a high HLB value emulsifier, 1-10% of a low HLB value emulsifier, 1-20% of solid grease, 5-25% of liquid grease, 1-15% of polyol and the balance deionized water. The invention also provides a preparation method of the nano emulsion. The method includes: firstly mixing the emulsifiers with grease to obtain an oil phase component, mixing the polyol with deionized water to obtain an aqueous phase component, respectively heating the oil phase component and the aqueous phase component in a water bath pot till complete dissolution, then adding the oil phase component into the aqueous phase component, adjusting the temperature until blue appears in the system obviously, recording the sample temperature at the moment, i.e. PIT (phase inversion temperature), conducting heat preservation for 0-10min, then stopping heating, and performing rapid cooling to room temperature, thus obtaining the nano emulsion prepared by phase inversion temperature method. The nano emulsion prepared by the method provided by the invention has uniform particles and good stability, and the energy consumption is greatly reduced in the preparation process, and the operation process and preparation cost are saved.

Description

Technical field [0001] The invention belongs to the field of chemical engineering, and relates to a cosmetic, specifically a nanoemulsion and a preparation method using a phase transition temperature method. Background technique [0002] Nanoemulsions are favored by people in the industry due to their thermodynamic stability, small particle size, good permeability promotion, and enhanced utilization of active ingredients. In recent years, there have been more and more studies on nanoemulsions. [0003] The preparation process of nanoemulsion can be divided into high-energy emulsification method and low-energy emulsification method from the source of emulsification energy. The high-energy emulsification method mainly provides a large amount of energy through methods such as high-speed stirring, ultrasound, and high-pressure homogenization, so that large droplets are broken into small droplets to form a nanoemulsion. The low-energy emulsification method mainly uses the physical and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/06A61K8/86A61Q19/00
CPCA61K8/068A61K8/86A61K2800/10A61Q19/00
Inventor 张婉萍张燎原朱海洋
Owner SHANGHAI INST OF TECH
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