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Hydroxyapatite nano peanut/gelatin self-assembled nano composite material and preparation method thereof

A nanocomposite material, hydroxyapatite technology, applied in the field of biomedical materials, can solve problems such as energy consumption, weak interaction between hydroxyapatite and gelatin, and nanostructure damage

Inactive Publication Date: 2017-07-21
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention overcomes the weak interaction between hydroxyapatite and gelatin due to the lack of active sites for interaction between hydroxyapatite and gelatin in the existing nanocomposite process through hydroxyapatite powder and gelatin , it is difficult to form a self-assembled nanostructure, and the residual surfactant in the hydroxyapatite powder leads to biocompatibility problems, energy consumption, cost increase, nanostructure damage, and reduced surface activity caused by calcination to remove residual surfactant And other issues

Method used

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  • Hydroxyapatite nano peanut/gelatin self-assembled nano composite material and preparation method thereof
  • Hydroxyapatite nano peanut/gelatin self-assembled nano composite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Take 0.5 g of hydroxyapatite nano-peanut powder, and super-disperse it in 10 mL of water for 0.5 minutes to make a uniformly dispersed hydroxyapatite dispersion, which is ready for use;

[0026] (2) Add 0.5g of gelatin powder to the hydroxyapatite dispersion obtained in the previous step, swell at room temperature for 1 hour, then heat to 65°C, stir until the gelatin is completely dissolved, and continue to stir and homogenize for 1 hour to prepare hydroxyapatite limestone / gelatin mixture, set aside;

[0027] (3) Pour the mixture in step (2) into the mold, concentrate in vacuum at 65°C to 50% of the original weight, cool to 35°C and keep it warm for 2 hours, put it into a freeze dryer at -2 to -5°C and freeze-dry Obtain hydroxyapatite nano-peanut / gelatin self-assembled nanocomposite;

[0028] figure 1 This is the TEM photo of the hydroxyapatite nano-peanut used. The hydroxyapatite is in the shape of a nano-peanut, with a length of 50-210 nanometers and a width of ...

Embodiment 2

[0034] Increase the amount of hydroxyapatite nano-peanut powder in step (1) in Example 1 to 1 g, and the other steps are the same as in Example 1. Obtain product with embodiment 1.

Embodiment 3

[0036] The amount of hydroxyapatite nano-peanut powder in step (1) in Example 1 is reduced to 0.1 g, and other steps are the same as in Example 1. Obtain product with embodiment 1.

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Abstract

The invention provides hydroxyapatite nano peanut / gelatin self-assembled nano composite material. The hydroxyapatite nano peanut / gelatin self-assembled nano composite material is prepared from hydroxyapatite nano peanuts and gelatin, wherein the mass ratio of the hydroxyapatite nano peanuts to the gelatin is 0.1-10 to 1. The length of the hydroxyapatite nano peanuts are nano rods 50-210 nanometers in length and 22-52 nanometers in width, and rich pits of 3-12 nanometers exist on the surface. The material is free of surfactants in the hydroxyapatite nano peanut preparing process, so that no biocompatibility problem is produced. In addition, the environment, cost and other problems brought by surfactant removal through high temperature calcination are avoided, and the damage of high temperature to a hydroxyapatite microstructure and surface activity is also avoided.

Description

technical field [0001] The technical scheme of the invention belongs to the field of biomedical materials, and relates to a hydroxyapatite nano-peanut / gelatin self-assembled nano-composite material and a preparation method thereof. Background technique [0002] Gelatin (Gelatin) is partially degraded by collagen in connective tissues such as animal skin, bone, sarcolemma, tendon, etc. to become white or light yellow, translucent, slightly shiny flakes or powder; it is a colorless, odorless, odorless Volatile, transparent and hard amorphous substance, soluble in hot water, insoluble in cold water, but can slowly absorb water and swell to soften. Gelatin can absorb water equivalent to 5-10 times its weight. Gelatin is one of the very important natural biopolymer materials, which has been widely used in food, medicine and chemical industries. Due to its excellent biodegradability and cytocompatibility, gelatin can be used in wound dressing, drug carrier and other fields. Nano...

Claims

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Application Information

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IPC IPC(8): A61L27/22A61L27/12A61L27/50
CPCA61L27/12A61L27/222A61L27/50A61L2400/12A61L2430/02
Inventor 刘超赵阳阳纪秀杰李颖李全
Owner HEBEI UNIV OF TECH
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