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pH-sensitive large-inner-diameter multiwalled carbon nanotube dual drug loading system, and preparation method thereof

A technology of multi-walled carbon nanotubes and double drug loading, which can be used in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. Large and other problems, to achieve the effect of improving the overall drug load, large external surface area, and high internal capacity

Active Publication Date: 2017-07-28
STOMATOLOGICAL HOSPITAL TIANJIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are two problems in the application of commonly used chemotherapeutic drugs in clinical practice: one is poor recognition of tumor cells, high toxicity and side effects, while killing tumor cells, it will also damage some normal tissue cells; Fast, low bioavailability, requires multiple injections of large doses to maintain the drug concentration inside the tumor cells to reach the therapeutic level

Method used

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  • pH-sensitive large-inner-diameter multiwalled carbon nanotube dual drug loading system, and preparation method thereof
  • pH-sensitive large-inner-diameter multiwalled carbon nanotube dual drug loading system, and preparation method thereof
  • pH-sensitive large-inner-diameter multiwalled carbon nanotube dual drug loading system, and preparation method thereof

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Experimental program
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Embodiment 1

[0029] A method for preparing a pH-sensitive large-inner-diameter multi-walled carbon nanotube dual drug-loading system, comprising the steps of:

[0030] (1) Take 300mg of large internal diameter multi-walled carbon nanotubes (abbreviated as LID-MWCNTs, the electron microscope photo of which is shown in figure 1 ), put it into a crucible, and heat it in an air environment in a calciner. The heating process is to heat from room temperature to 400 °C at 30 °C min-1, keep for 3 hours, and cool to room temperature;

[0031] (2) Dip the LID-MWCNTs obtained in step (1) into 6mol L -1 Stir in hydrochloric acid aqueous solution for 6 hours, discard the supernatant, wash and centrifuge with ultrapure water until the pH reaches neutral, and dry under vacuum at 40°C;

[0032] (3) Put the LID-MWCNTs obtained in step (2) into a mixed acid made of nitric acid and sulfuric acid with a volume ratio of 1:3, stir in an oil bath at 100°C for 30 min; neutralize with NaOH saturated aqueous solut...

Embodiment 2

[0041] A method for preparing a pH-sensitive large-inner-diameter multi-walled carbon nanotube dual drug-loading system, comprising the steps of:

[0042] (1) Take 200 mg of large-inner-diameter multi-walled carbon nanotubes (abbreviated as LID-MWCNTs) and put them into a crucible, and heat them in an air environment in a calciner. 5h, cooled to room temperature;

[0043] (2) Dip the LID-MWCNTs obtained in step (1) into 3mol L -1 Stir in hydrochloric acid aqueous solution for 12 hours, discard the supernatant, wash and centrifuge with ultrapure water until the pH reaches neutral, and dry under vacuum at 40°C;

[0044] (3) Put the LID-MWCNTs obtained in step (2) into a mixed acid made of nitric acid and sulfuric acid with a volume ratio of 1:3, stir in an oil bath at 100°C for 25 min; neutralize with NaOH saturated aqueous solution until the pH is Neutral to obtain suspension 1, put suspension 1 into a dialysis bag with a molecular weight cut-off of 8000 for dialysis in ultra...

Embodiment 3

[0053] A method for preparing a pH-sensitive large-inner-diameter multi-walled carbon nanotube dual drug-loading system, comprising the steps of:

[0054] (1) Take 400 mg of large inner diameter multi-walled carbon nanotubes (abbreviated as LID-MWCNTs) and put them into a crucible, and heat them in an air environment in a calciner. 1h, cooled to room temperature;

[0055] (2) Dip the LID-MWCNTs obtained in step (1) into 4mol L -1 Stir in hydrochloric acid aqueous solution for 8 hours, discard the supernatant, wash and centrifuge with ultrapure water until the pH reaches neutral, and dry under vacuum at 40°C;

[0056] (3) Put the LID-MWCNTs obtained in step (2) into a mixed acid made of nitric acid and sulfuric acid with a volume ratio of 1:3, stir in an oil bath at 100°C for 35 minutes; neutralize with NaOH saturated aqueous solution until the pH is Neutral to obtain suspension 1, put suspension 1 into a dialysis bag with a molecular weight cut-off of 14,000 for dialysis in ...

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Abstract

The invention discloses a pH-sensitive large-inner-diameter multiwalled carbon nanotube dual drug loading system (CDDP@O-LID-MWCNTs-PEG-FA-DOX for short), and a preparation method thereof. The preparation method comprises following steps: 1, heating of large-inner-diameter multiwalled carbon nanotube; 2, acid treatment; 3, oxidation; 4, filtering, drying, and obtaining of an obtained solid substance; 5, preparing of a cis-platinum-containing suspending liquid; 6, preparing of CDDP@O-LID-MWCNTs-PEG; 7, preparing of CDDP@O-LID-MWCNTs-PEG-FA; and 8, preparing of the CDDP@O-LID-MWCNTs-PEG-FA-DOX. The CDDP@O-LID-MWCNTs-PEG-FA-DOX is large in internal capacity and the external surface area, so that total drug loading capacity is increased; a polyethylene glycol-folic acid-doxorubicin tertiary structure blocking structure is formed on the surface of carbon nanotube, so that pH sensitive release of cis-platinum and doxorubicin is realized.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a pH-sensitive large-inner-diameter multi-walled carbon nanotube dual drug-loading system and a preparation method. Background technique [0002] Due to the characteristics of the anatomical structure and radiation sensitivity of many malignant tumors, the resection range of surgical treatment and the therapeutic effect of radiotherapy are limited, so chemotherapy plays an important role in their comprehensive treatment. At present, there are two problems in the application of commonly used chemotherapeutic drugs in clinical practice: one is poor recognition of tumor cells, high toxicity and side effects, while killing tumor cells, it will also damage some normal tissue cells; Fast, low bioavailability, requires multiple injections of large doses to maintain the drug concentration inside the tumor cells to reach the therapeutic level. Therefore, researchers hope that by using appropri...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/02A61K47/60A61K31/704A61K33/24A61P35/00
CPCA61K9/0092A61K31/704A61K33/24A61K47/02A61K2300/00
Inventor 隋磊杨涛王剑张俊江王娉婷吴珍珍
Owner STOMATOLOGICAL HOSPITAL TIANJIN MEDICAL UNIV
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