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A dimer flavonoid component in hemlock longbract and its separation method and application

A separation method and dimer technology, applied in the fields of organic chemistry, antidote, drug combination, etc., to achieve the effect of good controllability and reproducibility, not easy to run off, and reduce sample loss

Active Publication Date: 2019-05-10
ZUNYI MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far there is no report on the extraction and separation of chemical components in the bark of hemlock hemlock

Method used

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  • A dimer flavonoid component in hemlock longbract and its separation method and application
  • A dimer flavonoid component in hemlock longbract and its separation method and application
  • A dimer flavonoid component in hemlock longbract and its separation method and application

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Embodiment 1

[0022] The preparation method of dimer flavonoid compound of the present invention comprises the following steps:

[0023] 1) Take 3.7kg of dry bark of hemlock hemlock, after crushing, extract 3 times with 95% ethanol at room temperature, each time for 7 days, concentrate under reduced pressure to obtain 610g of ethanol extract;

[0024] 2) After dispersing the ethanol extract in step 1) in water, extract with petroleum ether, ethyl acetate and n-butanol successively for 3 times, and concentrate under reduced pressure to obtain extracts of various parts;

[0025] 3) Take 388 g of the extract from the ethyl acetate part in step 2), apply it to silica gel column chromatography, and use petroleum ether-ethyl acetate to gradient elution at volume ratios of 3:1, 1:1, 1:2, and 10:1. Combined with the TLC detection method, it is divided into 5 components according to the polarity, Fr.1~Fr.5, and each of the following components is combined with TLC analysis;

[0026] 4) Pass the fou...

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Abstract

The invention discloses a method for separating and purifying a new compound in tsuga longibracteata and an application of the new compound. The method is characterized in that the new compound is separated and purified from the tsuga longibracteata with a conventional extracting separation method in combination with a modern separation technology and the method comprises a solvent soaking extraction method, an extraction separation method, a normal phase column chromatography separation method, a semi-preparative high-performance liquid chromatographic separation method and the like. The new compound obtained through separation and purification is named as tsugadiflavonol A. By means of the extraction separation method of the new ingredient, the new dimer flavone ingredient is extracted and separated from the tsuga longibracteata, and a material basis is provided for further pharmacological and pharmacodynamic research of the tsuga longibracteata. Preliminary activity research proves that tsugadiflavonol A has a better antioxidation function and has a good development and application prospect.

Description

technical field [0001] The invention relates to separation and extraction technology in the chemical field, in particular to a dimer flavanol compound in hemlock hemlock, its separation preparation method and application. Background technique [0002] Longibractea (Tsuga longibracteata) belongs to a remnant species of gymnosperm Pinaceae Hemlock, distributed in Guangdong, Jiangxi, Guangxi, Fujian, Hunan, Guizhou and other places, and is a unique plant in my country. The trunk of this tree is tall and straight, with high hardness, excellent material, wide range of uses, and high economic value. The bark can be extracted and glued, and can be bone-bonded. [0003] The main components of hemlock plants are lignans, triterpenoids and flavonoids. Flavonoids are a class of polyphenolic compounds that exist in a variety of plants and have different biological activities and pharmacological effects. So far there is no report on the extraction and separation technology of chemical ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/22A61P39/06
CPCC07D493/22
Inventor 肖世基刘贵园张茂生
Owner ZUNYI MEDICAL UNIVERSITY
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