Pharmaceutical composition for preparing oral solid preparation of indissolvable drugs

A technology for insoluble drugs and solid preparations, which is used in drug delivery, medical preparations containing active ingredients, and pharmaceutical formulations, and can solve problems such as reducing bioavailability and increasing the number of drug administrations.

Inactive Publication Date: 2017-08-29
JIANGSU YABANG AIPUSEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For drugs with a short half-life in vivo, an excessively fast elimination rate not only increases the number of drug administrations, but also reduces bioavailability

Method used

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Embodiment Construction

[0018] In order to further illustrate the technical means and effects that the present invention adopts to achieve the predetermined purpose, please refer to the following detailed description of the present invention. It should be understood that these embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention. After reading After discovering the present invention, modifications to various equivalent forms of the present invention by those skilled in the art all fall within the scope defined by the appended claims of the present application.

[0019] The pharmaceutical composition containing telmisartan, loratadine, berberine hydrochloride and furosemide prepared by hot-melt granulation in the present invention and its preparation method are as follows: the raw material and the stabilizer polyethylene glycol 3350. Put lactose in a granulation pot and start stirring, mix at a low speed for 5 minutes, heat to ob...

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Abstract

The invention discloses a pharmaceutical composition for preparing an oral solid preparation of indissolvable drugs, wherein the indissolvable drugs include telmisartan, loratadine, berberine hydrochloride and furosemide. Solid granules of the indissolvable drugs can be prepared by mixing the indissolvable drugs with a certain amount of stabilizing agents, and then performing hot-melting extrusion, melting granulation or spray drying. By adopting the technical scheme, the prepared granules are reduced in particle size, reduced in drug granule gathering, and easy to infiltrate and disperse, so that the dissolution rate and dissolution of telmisartan, loratadine, berberine hydrochloride and furosemide in dissolution medium can be increased, and meanwhile the chemical stability cannot be reduced, and the quality of the product is good.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preparing oral solid preparations of insoluble drugs, in particular to a combination of solid particles with telmisartan, loratadine, berberine hydrochloride and furosemide as active ingredients things. Background technique [0002] Bioavailability refers to the extent and rate at which a drug is absorbed into the blood circulation. In new drug research, improving the bioavailability of insoluble active ingredients is a very important task. According to reports, more than one-third of the drugs in the "United States Pharmacopoeia" are water-insoluble drugs, and about 40% of the drugs are currently restricted due to solubility problems. [0003] Drugs generally need to go through four stages of absorption, distribution, metabolism and excretion when entering the body. The bioavailability of drugs is affected by many aspects, mainly including water solubility, permeability and first-pass effect ...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K9/16A61K31/4184A61K31/4545A61K31/4375A61K31/341
CPCA61K9/0053A61K9/1605A61K9/1682A61K31/341A61K31/4184A61K31/4375A61K31/4545
Inventor 陈再新葛育红王勇军王淑娟朱峰
Owner JIANGSU YABANG AIPUSEN PHARMA
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