Tadalafil oral dispersible film and preparing method thereof
A technology of tadalafil and dispersing film, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc. Additive leakage, low dissolution rate, etc., to achieve excellent stability, prevent film damage, and improve dissolution rate
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[0068] 1. The preparation of embodiment 1
[0069] The following process was carried out to produce an orodispersible film comprising tadalafil as an active ingredient. Using a blender (i.e. EuroStar Digital) was used for preparation and stirred at a speed of 300 rpm to 1000 rpm.
[0070] 2 g of sodium lauryl sulfate (ie SLS, surfactant) was added to 200 g of purified water in preparation vessel 1 and completely dissolved by stirring. 20 g of tadalafil was added to the completely dissolved solution and dispersed completely by stirring again. 7 g of polysorbate 20, 7 g of polyethylene glycol 400, 7 g of concentrated glycerol (PALMERA G995) and 7 g of sorbitol solution were added to the semi-finished product prepared and stirred again. 6 g croscarmellose sodium, 12 g microcrystalline cellulose, 4 g sucralose and 2 g titanium oxide were added and stirred again.
[0071] 2g of L-menthol (ie, flavor ingredient) was put into a beaker (ie, preparation container 2), and mixed wi...
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