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Medicinal composition for treating cachexia and applications of medicinal composition

A composition and cachexia technology, applied in the directions of drug combination, metabolic diseases, pharmaceutical formulations, etc., can solve the problems of short duration of effect of cachexia, insignificant effect of weight gain, etc., and achieve amazing therapeutic effect, prolongation of survival period, and broad clinical practice. The effect of the application foreground

Active Publication Date: 2017-09-08
CHANGCHUN NUOSAI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the significant side effects of long-term treatments and the shorter duration of their effect on cachexia, they are more suitable for patients with a short expected survival time, and in which the effect of weight gain is not obvious, and the patient's survival is not prolonged

Method used

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  • Medicinal composition for treating cachexia and applications of medicinal composition
  • Medicinal composition for treating cachexia and applications of medicinal composition
  • Medicinal composition for treating cachexia and applications of medicinal composition

Examples

Experimental program
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Effect test

Embodiment 1

[0034] This embodiment provides a pharmaceutical composition. The active ingredients in the pharmaceutical composition are: cytarabine and ketorolac, and the mass ratio of the two is 1.5:1.

Embodiment 2

[0036] This embodiment provides a pharmaceutical composition, the active ingredients in the pharmaceutical composition are: cytarabine and ketorolac trometamol, the mass ratio of the two is 3:1.

Embodiment 3

[0038] This embodiment provides a pharmaceutical composition, the active ingredients in the pharmaceutical composition are: cytarabine hydrochloride and ketorolac, the mass ratio of the two is 3:1.

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PUM

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Abstract

The invention relates to applications of cytarabine or an analogue of cytarabine and ketorolac or an analogue of ketorolac in treating cachexia, and in particular provides a medicinal composition for treating cachexia. According to the scheme, for the first time, one or more of cytarabine or the analogue of cytarabine and ketorolac or the analogue of ketorolac are creatively adopted as the active ingredients of the composition for treating cachexia, and remarkable treatment effects are obtained in the animal experiment. Based on the severity degree of cachexia, the medicinal composition has the broad clinical application prospect.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a pharmaceutical composition containing cytarabine and ketorolac and its application. Background technique [0002] The term cachexia is derived from the Greek words "kakos" and "hexis", which literally means "bad condition". (Cachexia as a major underestimated and unmet medical need: facts and numbers J Cachexia Sarcopenia Muscle (2010) 1:1–5). The main symptoms of cachexia include weight loss, muscle wasting, fatigue and loss of appetite. Cachexia is medically defined as weight loss and physical weakness that cannot be reversed with increased nutrition. Cachexia is common in cancer, AIDS, sepsis, severe trauma, COPD, multiple sclerosis, congestive heart failure, tuberculosis, familial amyloid polyneuropathy, chronic kidney disease, cystic fibrosis, type I diabetes and other progressive Sexual chronic diseases (Biology of Cachexia, J Natl Cancer Inst(1997) 89(23):17...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7068A61K31/407A61P1/14A61P3/00A61P21/00A61P39/00
CPCA61K31/407A61K31/7068A61K2300/00
Inventor 张东旭
Owner CHANGCHUN NUOSAI BIOTECH CO LTD
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