A kind of pharmaceutical composition and application thereof for treating cachexia

Abstract

The invention relates to the application of cytarabine or its analogs and ketorolac or its analogs in treating cachexia, and specifically provides a pharmaceutical composition for treating cachexia. For the first time in the present invention, one or more of cytarabine or its analogues and ketorolac or its analogues are used as the active ingredients of the composition for the treatment of cachexia, which has shown surprising therapeutic effects in animal experiments curative effect. Based on the severity of cachexia, the present invention has broad clinical application prospects.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a pharmaceutical composition containing cytarabine and ketorolac and its application. Background technique [0002] The term cachexia is derived from the Greek words "kakos" and "hexis", which literally means "bad condition". (Cachexia as a major underestimated and unmet medical need: facts and numbers J Cachexia Sarcopenia Muscle (2010) 1:1–5). The main symptoms of cachexia include weight loss, muscle wasting, fatigue and loss of appetite. Cachexia is medically defined as weight loss and physical weakness that cannot be reversed with increased nutrition. Cachexia is common in cancer, AIDS, sepsis, severe trauma, COPD, multiple sclerosis, congestive heart failure, tuberculosis, familial amyloid polyneuropathy, chronic kidney disease, cystic fibrosis, type I diabetes and other progressive Sexual chronic diseases (Biology of Cachexia, J Natl Cancer Inst(1997) 89(23):17...

AI Technical Summary

Problems solved by technology

Due to the significant side effects of long-term treatments and the shorter duration of their effect on cachexia, they are more suitable for patients with a short expected survival time, and in which the effect of weight gain is not obvious, and the patient's survival is not prolonged

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