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Application of a kind of medicine in the preparation of the medicine for reducing the expression of ll-37

A technology of LL-37 and medicine, which is applied in the new use of medicine and the application field of medicine, and can solve the problems of undisclosed medicine application and so on

Active Publication Date: 2021-07-09
SHANGHAI PHARMA GRP QINGDAO GROWFUL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention is an improved invention based on the CN 201010212156.8 patent. The content of the patent document cited in the present invention does not disclose the application of the drug in the drug for reducing the expression of LL-37

Method used

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  • Application of a kind of medicine in the preparation of the medicine for reducing the expression of ll-37
  • Application of a kind of medicine in the preparation of the medicine for reducing the expression of ll-37
  • Application of a kind of medicine in the preparation of the medicine for reducing the expression of ll-37

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The pharmaceutical tablet for reducing the expression of LL-37 is made of the bulk drug of the following parts by weight:

[0036]

[0037]

[0038] The preparation method of the medicine tablet comprises the following steps: taking ginseng, coptis, vinegar corydalis, hawthorn and half the amount of astragalus in the raw materials, pulverizing them into fine powder, and decocting the remaining eight-flavored raw materials and the remaining astragalus twice with water , 2 hours for the first time, 1.5 hours for the second time, combine the decoction, filter, and when the filtrate is concentrated to 90°C, the relative density is 1.06-1.12, let it cool, add double the amount of ethanol to precipitate, take the supernatant, and recover Ethanol, and concentrated to 90 ° C relative density of 1.20 ~ 1.22 paste, mixed with the above powder, made into granules, dried, compressed into 1000 tablets (small tablets), sugar-coated or film-coated tablets, or compressed into 500 ...

Embodiment 2

[0041] The medicine capsule for reducing the expression of LL-37 is made of the bulk drug of the following parts by weight:

[0042]

[0043]The preparation method of the drug capsule comprises the following steps: taking ginseng, coptis, vinegar corydalis, hawthorn and half of the astragalus in the raw materials, pulverizing them into fine powder, and decocting the remaining eight-flavored raw materials and the remaining astragalus twice with water , 2 hours for the first time, 1.5 hours for the second time, combine the decoction, filter, and when the filtrate is concentrated to 90°C, the relative density is 1.06-1.12, let it cool, add double the amount of ethanol to precipitate, take the supernatant, and recover Ethanol, and concentrated to a clear paste with a relative density of 1.20 to 1.22 at 90°C, mixed with the above-mentioned medicinal powder, and made into capsules.

[0044] It is used for preparing the medicine for reducing the expression of LL-37, and said reduc...

Embodiment 3

[0046] The drug granules used to reduce the expression of LL-37 are made of the following raw materials in parts by weight:

[0047]

[0048] The preparation method of the drug granules comprises the following steps: taking ginseng, coptis, vinegar corydalis, hawthorn and half of astragalus in the raw materials, pulverizing them into fine powder, decocting the remaining eight-flavored raw materials and the remaining astragalus with water twice , 2 hours for the first time, 1.5 hours for the second time, combine the decoction, filter, and when the filtrate is concentrated to 90°C, the relative density is 1.06-1.12, let it cool, add double the amount of ethanol to precipitate, take the supernatant, and recover Ethanol, and concentrated to a clear paste with a relative density of 1.20 to 1.22 at 90°C, mixed with the above-mentioned medicinal powder to make granules. It is used for preparing the medicine for reducing the expression of LL-37, and reducing the expression of LL-37...

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Abstract

The invention discloses an application of a medicine in the preparation of a medicine for reducing the expression of LL-37. The medicine is made of the following raw materials in parts by weight: 100-150 parts by weight of Radix Astragali, 80-120 parts by weight of Codonopsis Codonopsis, and 60-120 parts by weight of Salvia Miltiorrhiza 100 parts by weight, Pueraria 60-100 parts by weight, Epimedium 60-100 parts by weight, Hawthorn 60-100 parts by weight, Rehmannia glutinosa 40-80 parts by weight, Angelica sinensis 40-80 parts by weight, Coptidis 40-80 parts by weight, vinegar Corydalis 40-80 parts by weight, 40-80 parts by weight of ganoderma lucidum, 20-30 parts by weight of ginseng, and 20-30 parts by weight of roasted licorice. The pharmaceutical composition of the invention can reduce the concentration of LL-37 in the supernatant of peripheral blood mononuclear cells of patients with unstable angina pectoris.

Description

technical field [0001] The invention relates to a new application of a medicine, in particular, the invention relates to the application of a medicine in the preparation of a medicine for reducing the expression of LL-37, which belongs to the field of traditional Chinese medicine application. Background technique [0002] Antibacterial peptides are cationic facultative peptides with different sequences and structures produced by various tissues and cells of higher organisms. The antibacterial polypeptides in the human body are divided into: defensins and cathepsin inhibitors. LL-37 is the only cathepsin antibacterial polypeptide found in the human body so far. It is composed of human cationic microbial protein 18 in serine The active C-terminal fragment produced by the enzymatic hydrolysis of protease 3 has 37 amino acid residues and the first two amino acids at the N-terminal are both leucine (L), so it is called LL-37. As an important part of the innate immune system, LL-...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61P43/00A61P9/10
CPCA61K36/074A61K36/232A61K36/258A61K36/296A61K36/344A61K36/481A61K36/484A61K36/488A61K36/537A61K36/66A61K36/718A61K36/734A61K36/804A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 丁彦春吕英刚仇同革刘万亭
Owner SHANGHAI PHARMA GRP QINGDAO GROWFUL PHARMA CO LTD