Two-dimensional flexible device for Raman quantitation and imaging and preparation method thereof

A Mann quantitative and device technology, applied in the field of two-dimensional flexible devices and their preparation, can solve the problems of difficult to obtain stable and highly reproducible signals, high preparation requirements, and complicated operations, and achieve fast SERS imaging analysis and simple operation. , excellent effect of two-dimensional structure

Active Publication Date: 2017-09-15
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods have improved the quantitative ability of SERS to a certain extent, but the preparation requirements are high, the operation is complicated, and it is difficult to obtain stable and reproducible signals, so it is difficult to be used in the detection of actual samples.

Method used

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  • Two-dimensional flexible device for Raman quantitation and imaging and preparation method thereof
  • Two-dimensional flexible device for Raman quantitation and imaging and preparation method thereof
  • Two-dimensional flexible device for Raman quantitation and imaging and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Combining figure 1 , to prepare the two-dimensional flexible device

[0023] The device is mainly assembled from AuNSs@1LG flakes and 1LG composite film with IS.

[0024] 1) Preparation of AuNSs@1LG flakes: first immerse a 1LG flake grown on copper foil into a 1mM ethanol solution of dodecyl mercaptan (DDT), let it stand at room temperature for one hour, take it out, and carefully wash it with water several times. Blow dry with high-purity nitrogen. Then the treated 1LG sheet was immersed in 1nM AuNSs ethanol solution, oscillated at 43°C under temperature control, and reacted at 350rpm for 18 hours, so that AuNSs self-assembled into a dense monolayer on the surface of 1LG. After the reaction, carefully wash with water and blow dry with nitrogen to obtain the AuNSs@1LG flakes.

[0025] 2) Preparation of 1LG composite film with IS: immerse a 1LG film grown on copper foil into an ethanol solution containing IS (the type of IS molecule can be selected accordin...

Embodiment 2

[0027] Example 2: Combining image 3 , using this two-dimensional flexible device for SERS quantitative detection and imaging of solution / solid samples

[0028] For solution samples (taking aqueous solution samples as an example), the device can directly float on the surface of the solution ( image 3 A). After obtaining the SERS signals of different concentrations of the analyte solution under the conventional Raman instrument, select the respective characteristic peaks of the IS and the analyte molecule, and divide the intensity value of the characteristic peak of the analyte by the intensity value of the IS characteristic peak, The standard curve can be obtained by plotting the concentration of the analyte. The standard curve method is used to realize the SERS quantitative detection of unknown concentration analytes.

[0029] For solid samples (take the residual pesticides on the surface of apples as an example), the device can be directly attached to the area to be test...

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Abstract

The invention relates to a two-dimensional flexible device for Raman quantitation and imaging analysis and a preparation method thereof. The device is composed of two single-layer graphene sheets (1LG) prepared by chemical vapor deposition and single-layer self-assembled gold nanostars (AuNSs) clamped between the two graphene sheets, and is fixed by a polymethyl methacrylate (PMMA) membrane. The method comprises the following steps: fixing an internal standard (IS) on the upper 1LG surface of the device, and detecting a to-be-detected substance by using the lower 1LG surface of the device, thereby simultaneously acquiring non-interfering IS and a surface enhanced Raman scattering (SERS) signal of the to-be-detected substance under excitation of light of certain wavelength, and further obtaining reliable SERS quantitative results by using the IS method. The device has an ultra-thin two-dimensional structure and excellent flexible characteristics and can be attached to the surface of any object to realize detection of multiple samples on solution and solid surfaces, and the SERS imaging result of the to-be-detected substance on the solid surface can be obtained based on the SERS signal. The device has excellent stability, reusability and structural variability, can be used for Raman quantitative detection and imaging study of multiple to-be-detected substances on multiple occasions, and has wide application prospects.

Description

1. Technical field [0001] The invention relates to a two-dimensional flexible device which can be used for Raman quantification and imaging and a preparation method thereof. 2. Background technology [0002] From the 1970s to the present, surface-enhanced Raman scattering (SERS) technology has been developed rapidly. SERS enhances the original weak Raman scattering signal by 10 8 It can not only provide structural information of the analyte molecule, but also realize ultra-sensitive detection down to single molecule, thus becoming a powerful analytical method. However, due to three reasons: (1) the SERS signal is highly sensitive to the substrate and the surrounding environment, making it susceptible to interference; (2) the SERS signal mainly originates from the "hot spot" region, rather than all the analyte molecules in contact with the substrate. , resulting in poor signal uniformity; (3) The complex interaction between the metal substrate and the analyte molecules will...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 鞠熀先郭景星陈云龙
Owner NANJING UNIV
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