Two-dimensional flexible device for Raman quantitation and imaging and preparation method thereof

A Mann quantitative and device technology, applied in the field of two-dimensional flexible devices and their preparation, can solve the problems of difficult to obtain stable and highly reproducible signals, high preparation requirements, and complicated operations, and achieve fast SERS imaging analysis and simple operation. , excellent effect of two-dimensional structure
CN107167464AActive Publication Date: 2017-09-15NANJING UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING UNIV
Publication Date
2017-09-15

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Abstract

The invention relates to a two-dimensional flexible device for Raman quantitation and imaging analysis and a preparation method thereof. The device is composed of two single-layer graphene sheets (1LG) prepared by chemical vapor deposition and single-layer self-assembled gold nanostars (AuNSs) clamped between the two graphene sheets, and is fixed by a polymethyl methacrylate (PMMA) membrane. The method comprises the following steps: fixing an internal standard (IS) on the upper 1LG surface of the device, and detecting a to-be-detected substance by using the lower 1LG surface of the device, thereby simultaneously acquiring non-interfering IS and a surface enhanced Raman scattering (SERS) signal of the to-be-detected substance under excitation of light of certain wavelength, and further obtaining reliable SERS quantitative results by using the IS method. The device has an ultra-thin two-dimensional structure and excellent flexible characteristics and can be attached to the surface of any object to realize detection of multiple samples on solution and solid surfaces, and the SERS imaging result of the to-be-detected substance on the solid surface can be obtained based on the SERS signal. The device has excellent stability, reusability and structural variability, can be used for Raman quantitative detection and imaging study of multiple to-be-detected substances on multiple occasions, and has wide application prospects.
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Description

1. Technical field

[0001] The invention relates to a two-dimensional flexible device which can be used for Raman quantification and imaging and a preparation method thereof. 2. Background technology

[0002] From the 1970s to the present, surface-enhanced Raman scattering (SERS) technology has been developed rapidly. SERS enhances the original weak Raman scattering signal by 10 8 It can not only provide structural information of the analyte molecule, but also realize ultra-sensitive detection down to single molecule, thus becoming a powerful analytical method. However, due to three reasons: (1) the SERS signal is highly sensitive to the substrate and the surrounding environment, making it susceptible to interference; (2) the SERS signal mainly originates from the "hot spot" region, rather than all the analyte molecules in contact with the substrate. , resulting in poor signal uniformity; (3) The complex interaction between the metal substrate and the analyte molecules will...

Claims

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