Preparation and application of label-free odd-even discriminator based on silver nanoclusters and graphene oxide

Abstract

The present invention belongs to the analytical chemistry optic logic gate technology field, and relates to a label-free, universal and fast-response fluorescent logic device synthetic method and the application thereof in digit odd-even discrimination. The method comprises: employing graphene oxide and silver nanoclusters protected by single stranded DNA as a detection platform, and adding DNAs with different sequences as signal input so as to obtain output of different fluorescence signals. The method combines nanometer materials to complete odd-even discrimination of decimal digits from 0 to 31 on the molecular level. Compared to the prior art, the serial logic device employs the high fluorescence quantum efficiency feature and the label-free label of noble-metal nanoclusters to combine with novel nanometer materials such as the graphene oxide and the like so as to rapidly realize the operation function of the odd-even discriminator and have latent application values at the aspects of disease diagnosis, molecular biology detection and cell imaging.

Description

Technical field [0001] The invention relates to a method for synthesizing a label-free, universal and fast-response parity discriminator and its application in the field of molecular logic. Background technique [0002] Throughout the development history of human society, the invention of the electronic computer has only appeared for 70 years, but it has achieved unparalleled achievements and has led to scientific and technological revolutions again and again. At present, the development of electronic computers is in the microelectronics period characterized by very large scale integrated circuits. Integrated circuits are based on semiconductor silicon and consist of logic circuits. These logic circuits convert all kinds of information into electrical signals for information transmission, processing and storage. All information is a series of binary codes based on "1" and "0", which represent high level and low level respectively. level. The development of this logic circuit c...

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Problems solved by technology

[0003] At present, molecular logic devices based on DNA self-assembly have made some progress, but it is still a great challenge to obtain low-cost and high-efficiency DNA molecular logic gates.

Most of the existing DNA fluorescent logic gates need to be labeled with fluorescent dyes. This method has great defects, such as high cost, labor-intensive, and poor light resistance of dyes. Therefore, a label-free molecule based on silver nanoclusters was developed. Logic devices are of great significance

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