Purifying method of pomalidomide

A purification method, the technology of polilidomide, applied in the direction of organic chemistry, etc., can solve the problem of insufficient purity of polilidomide, and achieve the effects of environmental friendliness, high yield, and easy operation
CN107188884AInactive Publication Date: 2017-09-22SHANGHAI INST OF PHARMA IND CO LTD +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI INST OF PHARMA IND CO LTD
Publication Date
2017-09-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a purifying method of pomalidomide. According to the purifying method, a pomalidomide crude product with high performance liquid phase chromatography purity ranging from 80 to 99% is mixed with a mixed solvent, and then crystallization is carried out; the mixed solvent is a mixture of an organic solvent and water; the organic solvent is an amide solvent or a ketone solvent; when the organic solvent is an amide solvent, the volume ratio of the amide solvent to water is controlled to be 4:1-8:1; and when the organic solvent is the ketone solvent, the volume ratio of the ketone solvent to water is controlled to be 3:1-1:3. The purifying method is simple and convenient in operation, high in yield and purity, and is capable of satisfying requirements on industrialized production in drug Good Manufacturing Practice.
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Description

[0001] This application is a divisional application of the following application: filing date: October 29, 2013; application number: 201310520848.2; invention title: "a purification method for polilidomide". technical field

[0002] The invention relates to a method for purifying polilidomide. Background technique

[0003] Pomalidomide, the English name is Pomalidomide, the chemical name is 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione, and its chemical structure is as follows:

[0004]

[0005] Polidomide is a new type of immunomodulator originally developed by Celgene. Polidomide is a derivative of thalidomide, which can regulate T cells and inhibit their proliferation, and play an immunoregulatory role; by activating natural killer ( natural killer) cells, promote the apoptosis of tumor cells, and are mainly used clinically for the treatment of multiple myeloma.

[0006] CN101253163 provides a kind of preparation method of high-purity polilidomide, the mixt...

Claims

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