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Uses of mangostin as phosphodiesterase 4 (PDE4) inhibitor

A technology of phosphodiesterase and mangostin, which can be used in medical preparations containing active ingredients, respiratory diseases, organic active ingredients, etc., and can solve problems such as diarrhea and nausea

Active Publication Date: 2017-10-03
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although PDE4 inhibitors have shown their beneficial pharmacological effects, such inhibitors have adverse effects such as diarrhea and nausea
There is no relevant report about α-mangostin as a PDE4 inhibitor

Method used

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  • Uses of mangostin as phosphodiesterase 4 (PDE4) inhibitor
  • Uses of mangostin as phosphodiesterase 4 (PDE4) inhibitor

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Embodiment Construction

[0013] pharmaceutically acceptable salt

[0014] The present invention contemplates that "pharmaceutically acceptable salts" of α-mangostin also have the same activity. In general, such salts are prepared, for example, by combining the free acid or base forms of these compounds with a stoichiometric amount of the appropriate base or acid in water or in an organic solvent or in a mixture of both. In general, non-aqueous media such as diethyl ether, ethyl acetate, ethanol, isopropanol or acetonitrile are preferred. Examples of acid addition salts include inorganic acid addition salts such as hydrochloride, hydrobromide, hydroiodide, sulfate, nitrate, and organic acid addition salts such as, for example, acetate, maleic acid Salt, fumarate, citrate, oxalate, succinate, tartrate, malate, mandelate and p-toluenesulfonate. Examples of base addition salts include inorganic salts such as sodium, potassium, calcium, ammonium, magnesium, aluminum and lithium salts; and organic bases s...

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PUM

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Abstract

The present invention relates to uses of a natural product mangostin or a pharmaceutically acceptable salt thereof as a phosphodiesterase 4 (PDE4) inhibitor, wherein the inhibition of the mangostin on the PDE4 can provide the good prospect for the treatment of PDE4-mediated diseases.

Description

technical field [0001] The invention relates to the new use of α-mangostin as a phosphodiesterase 4 (PDE4) inhibitor and its application in the preparation of medicines for treating diseases mediated by PDE4. Background technique [0002] Phosphodiesterase (PDES) effectively controls the concentration of cAMP and cGMP in the cell by hydrolyzing the important second messenger cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), thereby regulating the transmission of the second messenger in the body biochemical effect. They play an important role in physiological processes such as vision, smell, metabolism, muscle contraction, memory, immune response, neurotransmission, exocytosis, cell growth and differentiation, and are important targets for drug design. [0003] Phosphodiesterase 4 (PDE4) is a member of the PDE enzyme family, mainly distributed in various inflammatory cells, mast cells, macrophages, eosinophils, lymphocytes and epithelial cells,...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P11/06A61P11/00A61P43/00
CPCA61K31/352
Inventor 何细新罗海彬谭冰心黄仪有
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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