Use of Cistanche deserticola polysaccharide to prepare medicine for treating ischemic stroke

A polysaccharide and application technology of Cistanche deserticola is applied in the directions of drug combination, pharmaceutical formulation, organic active ingredient, etc., which can solve the problem that the protective effect of cerebral ischemia nerve damage has not yet been reported, and achieves improvement of cell survival rate, reduction of cell apoptosis rate, Attenuates the effect of cell damage

Active Publication Date: 2020-06-30
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have found that Cistanche deserticola polysaccharides have various pharmacological effects such as immune regulation, anti-aging, improvement of spleen deficiency, anti-virus and anti-tumor, and promotion of hematopoiesis. Hemorrhagic stroke treatment drugs have extremely high potential value and social significance

Method used

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  • Use of Cistanche deserticola polysaccharide to prepare medicine for treating ischemic stroke
  • Use of Cistanche deserticola polysaccharide to prepare medicine for treating ischemic stroke
  • Use of Cistanche deserticola polysaccharide to prepare medicine for treating ischemic stroke

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Cistanche deserticola polysaccharide is used as a medicine for treating ischemic stroke, and ischemic stroke is ischemic stroke in the acute phase or repair period, wherein the single application dose of Cistanche deserticola polysaccharide in cells is 0.05 μg / ml, and the dosage form of the medicine is The powder injection dosage form allowed in pharmacy.

Embodiment 2

[0034] Cistanche deserticola polysaccharide is used as a drug for treating ischemic stroke, and ischemic stroke is ischemic stroke in the acute phase or repair period, wherein the single application amount of Cistanche deserticola polysaccharide in cells is 0.5 μg / ml, and the dosage form of the drug is The powder injection dosage form allowed in pharmacy.

Embodiment 3

[0036] Cistanche deserticola polysaccharide is used as a medicine for treating ischemic stroke, and ischemic stroke is ischemic stroke in the acute phase or repair period, wherein the single application dose of Cistanche deserticola polysaccharide in cells is 5 μg / ml, and the dosage form of the medicine is medicament Medically approved powder injection dosage form.

[0037] The following cell experiments further illustrate the effects of the above-mentioned embodiments 1 to 3:

[0038] One experimental material

[0039] 1.1 PC12 cell culture

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Abstract

The invention discloses application of cistanche deserticola polysaccharides (CDPs) in preparing drug for treating ischemic stroke. Experiment results show that after oxygen-glucose deprivation reperfusion, the CDPs with concentration of 5ug / ml can remarkably increase cell survival rate, reduce cell membrane damage, stabilize calcium ion level and mitochondrial membrane potential in cells and lower cell apoptosis rate. The experiment results prove that the CDPs can reduce cell damage caused by oxygen-glucose deprivation reperfusion.

Description

technical field [0001] The invention relates to the application of Cistanche deserticola polysaccharide, in particular to the application of Cistanche deserticola polysaccharide as a medicine for treating ischemic stroke. Background technique [0002] Ischemic brain disease (ischemic brain disease), also known as ischemic stroke, has become one of the leading causes of death and disability worldwide, seriously threatening human life and health. Intravenous thrombolysis is considered to be the only effective and feasible treatment for stroke at present, but it is limited by the strict treatment time window and the risk of intracranial hemorrhage, making it difficult for a large number of patients to benefit from this treatment. Therefore, it is particularly important to find new prevention and treatment options for stroke treatment. [0003] A large number of studies in recent years believe that brain cell injury caused by interruption of cerebral blood flow and reperfusion ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61P9/10
CPCA61K31/715
Inventor 余建强刘悦刘宁李玉香赵玉萍
Owner NINGXIA MEDICAL UNIV
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