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Porous beta-tricalcium phosphate medicine sustained release system and preparation method thereof

A technology of tricalcium phosphate and tricalcium phosphate slurry, which is applied in the fields of drug devices, medical science, bone implants, etc., can solve the problems of lack of therapeutic effect, toxic side effects, etc. Effect

Pending Publication Date: 2017-11-03
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Problems solved by technology

[0002] Traditional drug administration methods are mainly oral administration, injection, etc. The blood drug concentration will fluctuate, with peaks and troughs. The peak concentration often exceeds the appropriate concentration, causing toxic and side effects, and the trough will be lower than the minimum therapeutic concentration, resulting in no therapeutic effect.

Method used

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  • Porous beta-tricalcium phosphate medicine sustained release system and preparation method thereof
  • Porous beta-tricalcium phosphate medicine sustained release system and preparation method thereof
  • Porous beta-tricalcium phosphate medicine sustained release system and preparation method thereof

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Embodiment Construction

[0038] The present invention will be further described below through specific embodiments in conjunction with the accompanying drawings. These embodiments are only used to illustrate the present invention, and are not intended to limit the protection scope of the present invention.

[0039] Such as figure 1 and figure 2 As shown, the invention provides a porous β-tricalcium phosphate drug sustained release system, comprising:

[0040] A first structure body 1 with a porous structure, which has a cavity with an open top, and the first structure body 1 is used for cell adhesion, crawling, value addition and drug release;

[0041] A second structure 2 with a porous structure matching the size of the cavity of the first structure 1 is disposed in the cavity of the first structure 1, and the second structure 2 is used to control the release rate of the drug;

[0042] There is a cavity with an open top in the second structure 2, which is used for loading medicine;

[0043] The m...

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Abstract

The invention discloses a porous beta-tricalcium phosphate medicine sustained release system and a preparation method thereof. The sustained release system comprises a first structure body with a porous structure, and a second structure body with the porous structure, wherein a cavity with an open top is arranged in the first structure body; the size of the second structure body is fit with the cavity of the first structure body, and the second structure body is arranged in the cavity of the first structure body; a cavity with the open top used for loading medicines is arranged in the second structure body; the first structure body and the second structure body are made of beta-tricalcium phosphate; and the hole diameter of the first structure body is more than that of the second structure body. The porous beta-tricalcium phosphate medicine sustained release system provided by the invention can improve the loading capacity of the sustained release medicine and release the medicine continuously; in addition, bone tissues can be repaired while the sustained release medicine takes effect, and thus the system is applicable to curing defects and infection of sclerous tissues such as the spine and long bones.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a porous β-tricalcium phosphate drug slow-release system and a preparation method thereof. Background technique [0002] Traditional drug administration methods are mainly oral administration, injection, etc. The blood drug concentration will fluctuate, with peaks and troughs. The peak concentration often exceeds the appropriate concentration, causing toxic and side effects, and the trough will be lower than the minimum therapeutic concentration, resulting in no therapeutic effect. . [0003] Therefore, there is an urgent need to construct a drug sustained-release system, which can continuously release drugs, is suitable for patients who need long-term medication, and does not require further treatment after application, which can effectively improve patient compliance. [0004] Bone tissue infection is a difficult problem in clinical orthopedics. Systemic medication is often difficul...

Claims

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Application Information

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IPC IPC(8): A61F2/28A61M31/00A61L27/12A61L27/56A61L27/54A61L27/50
CPCA61L27/12A61L27/50A61L27/54A61L27/56A61M31/00A61F2/28A61F2/30942A61F2002/2835A61F2002/30772A61F2002/3093A61L2300/602A61L2430/02A61M2210/02A61M2210/005
Inventor 管捷谢幼专韩辰赵杰
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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