Slow-release and anti-infective composite soft tissue repair material and preparation method thereof

A repair material and anti-infection technology, applied in medical science, prosthesis, etc., can solve the problems of complex preparation process of nanoparticles, lack of clinical application prospects, and unknown biological safety, so as to maintain effective drug concentration, reduce adverse reactions, EFFECTS OF DOSAGE REDUCTION OF DRUGS

Active Publication Date: 2017-11-07
EXCELLENCE MEDICAL TECH SUZHOU CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation process of the nanoparticles involved in these two patents is complicated, and the biological safety is unknown. Nanoparticles with small particle size (<50nm) may have certain cytotoxicity and lack clinical application prospects.

Method used

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  • Slow-release and anti-infective composite soft tissue repair material and preparation method thereof
  • Slow-release and anti-infective composite soft tissue repair material and preparation method thereof
  • Slow-release and anti-infective composite soft tissue repair material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A drug-loaded and sustained-release tissue repair material comprises decellularized small intestinal submucosa (SIS) and drug-loaded chitosan flakes. Chitosan powder is mixed with an antibacterial agent and dissolved, and shaped into a sheet-like material. SIS is prepared in a staggered way with an area of ​​10×10cm 2 slices, refer to figure 1 Lay the drug-loaded tablets (2) intermittently on the surface of the SIS (1) according to the diameter of the inhibition zone, and lay 6 tablets in total. The interlayers are fixed with medical chitosan adhesive, and pressed together under the pressure of -200mmHg.

[0028] The antibacterial effect of the material in vitro was observed by the inhibition zone method: it has effective antibacterial activity for 7-21 days against methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Escherichia coli.

[0029] Evaluate the cytotoxicity of the material according to the method specified...

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PUM

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Abstract

The invention relates to a slow-release and anti-infective composite soft tissue repair material and a preparation method thereof. The repair material is prepared from a biological material and media containing anti-infective components, wherein the media containing the anti-infective components are arranged between layers of the biological material or on the surface of the biological material at intervals according to the radius of an inhibition zone of a drug sensitive test, and a whole body is formed by the aid of a binding agent, suture lines or pressure. According to the slow-release and anti-infective composite soft tissue repair material and the preparation method thereof, the anti-infective components can be released effectively and continuously, meanwhile, biocompatibility of the biological material is not changed, the biological material is non-toxic and harmless, and the application prospect is good.

Description

technical field [0001] The invention belongs to the field of soft tissue repair materials and preparation thereof, in particular to a slow-release anti-infection composite soft tissue repair material and a preparation method thereof. Background technique [0002] Biomaterials are an important advance in the study of soft tissue repair materials. Representative materials that are resistant to infection and remodelable include synthetic biomaterials (such as P4HB, silk fibroin fibers, collagen, chitosan, etc.) and acellular matrix biomaterials. Compared with traditional non-absorbable polymer materials, biomaterials act as temporary tissue scaffolds after implantation in the body, and as the patch material degrades, host cells infiltrate it and produce autologous collagen fibers. Such an endogenous tissue remodeling process can achieve early local rapid revascularization, early entry of phagocytes, and difficulty in the formation of bacterial biofilms, so it has a certain resi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/58A61L27/56A61L27/54A61L27/36A61L27/20
CPCA61L27/20A61L27/3633A61L27/54A61L27/56A61L27/58A61L2300/404A61L2300/604C08L5/08
Inventor 张剑程文悦刘耀婷
Owner EXCELLENCE MEDICAL TECH SUZHOU CO LTD
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