Zinc oxide coating-hydroxyapatite coating with biological activity and antibacterial property as well as preparation method and application thereof

A hydroxyapatite, bioactive technology, applied in coating, metal material coating process, drug delivery, etc., to achieve the effects of high efficiency, promotion of antibacterial activity, and easy operation

Active Publication Date: 2021-07-09
北京科技大学天津学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, the zinc oxide coating-hydroxyapatite coating implant material with biological activity and antibacterial properties, and the research and patent on the method of inducing biological activity and antibacterial properties through ultraviolet light irradiation on zinc oxide coated magnesium alloys have not been seen. to report

Method used

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  • Zinc oxide coating-hydroxyapatite coating with biological activity and antibacterial property as well as preparation method and application thereof
  • Zinc oxide coating-hydroxyapatite coating with biological activity and antibacterial property as well as preparation method and application thereof
  • Zinc oxide coating-hydroxyapatite coating with biological activity and antibacterial property as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A method for preparing a zinc oxide coating-hydroxyapatite coating with biological activity and antibacterial properties, the steps are as follows:

[0034] 1) Process the AZ31 magnesium alloy into a block of 10mm×10mm×2mm, and use 800 # , 1200 # , 2000 # Polished with SiC sandpaper, then ultrasonically cleaned in acetone, deionized water, and ethanol for 10 minutes, and dried with hot air.

[0035] 2) Preparation of ZnO coating solution: Zn(CH 3 COO) 2 2H 2 O or Zn(NO 3 ) 2 Provide Zn 2+ source to NaHCO 3 , NaOH or NH 3 ·H 2 O provides OH - source; the OH - The source aqueous solution was added dropwise to Zn 2+ After the source aqueous solution is mixed, the pH value of the mixed solution is finally adjusted to 9 with dilute alkali, and magnetically stirred for 2 hours; wherein, the Zn in the mixed solution 2+ The concentration is 0.43mol / L.

[0036] 3) Preparation of ZnO coating: soak the pretreated magnesium alloy sample in the ZnO coating solution, p...

Embodiment 2

[0042] A method for preparing a zinc oxide coating-hydroxyapatite coating with biological activity and antibacterial properties, the steps are as follows:

[0043] 1) Process the AZ31 magnesium alloy into a block of 10mm×10mm×2mm, and use 800 # , 1200 # , 2000 # Polished with SiC sandpaper, then ultrasonically cleaned in acetone, deionized water, and ethanol for 10 minutes, and dried with hot air.

[0044] 2) Preparation of ZnO coating solution: Zn(CH 3 COO) 2 2H 2 O or Zn(NO 3 ) 2 Provide Zn 2+ source to NaHCO 3 , NaOH or NH 3 ·H 2 O provides OH - source; the OH - The source aqueous solution was added dropwise to Zn 2+ After the source aqueous solution is mixed, the pH value of the mixed solution is finally adjusted to 7 with dilute alkali, and magnetically stirred for 2 hours; wherein, Zn in the mixed solution 2+ The concentration is 0.43mol / L.

[0045] 3) Preparation of ZnO coating: soak the pretreated magnesium alloy sample in the ZnO coating solution, place...

Embodiment 3

[0051] A method for preparing a zinc oxide coating-hydroxyapatite coating with biological activity and antibacterial properties, the steps are as follows:

[0052] 1) Process the AZ31 magnesium alloy into a block of 10mm×10mm×2mm, and use 800 # , 1200 # , 2000 # Polished with SiC sandpaper, then ultrasonically cleaned in acetone, deionized water, and ethanol for 10 minutes, and dried with hot air.

[0053] 2) Preparation of ZnO coating solution: Zn(CH 3 COO) 2 2H 2 O or Zn(NO 3 ) 2 Provide Zn 2+ source to NaHCO 3 , NaOH or NH 3 ·H 2 O provides OH - source; the OH - The source aqueous solution was added dropwise to Zn 2+ After the source aqueous solution is mixed, the pH value of the mixed solution is finally adjusted to 7 with dilute alkali, and magnetically stirred for 2 hours; wherein, Zn in the mixed solution 2+ The concentration is 0.43mol / L.

[0054] 3) Preparation of ZnO coating: soak the pretreated magnesium alloy sample in the ZnO coating solution, place...

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PUM

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Abstract

The invention discloses a zinc oxide coating-hydroxyapatite coating with biological activity and antibacterial property as well as a preparation method and an application thereof. The zinc oxide coating-hydroxyapatite coating comprises an alkaline zinc oxide coating and a hydroxyapatite coating, the alkaline zinc oxide coating is excited by ultraviolet light to generate .OH on the surface to form a zinc oxide coating-hydroxyapatite coating with the hydroxyapatite coating; and the preparation method comprises the following steps: exciting the surface of the alkaline zinc oxide coating to generate. OH, and reacting with SBF simulated body fluid to form the zinc oxide coating-hydroxyapatite coating. The zinc oxide coating-hydroxyapatite coating is used for preparing an orthopedic implant. The method is low in cost, high in efficiency, simple and easy to implement and environmentally friendly, and the zinc oxide coating-hydroxyapatite coating prepared through the method has good biological activity and antibacterial performance and has high commercial popularization value.

Description

technical field [0001] The invention relates to a zinc oxide coating-hydroxyapatite coating with biological activity and antibacterial performance, a preparation method and application. Background technique [0002] As representatives of biomedical metal materials, traditional medical metal stainless steel, titanium alloys, Ni / Ti shape memory alloys and cobalt-based alloys have good comprehensive mechanical properties and good corrosion resistance, and are widely used in bone repair, cardiovascular, dental, etc. fields are widely used. However, the biggest clinical problem is that these alloys are non-degradable and must be taken out after a second operation after the bone wound has healed, causing economic pressure and mental pain to the patient. As a promising orthopedic implant, biodegradable magnesium and its alloys are widely used in fixation devices, vascular stents and hemostasis due to their good biosafety and biocompatibility, as well as physical and mechanical pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/30A61L27/32A61L27/54A61L27/58A61L27/04C23C26/00
CPCA61L27/54A61L27/32A61L27/306A61L27/58C23C26/00A61L27/047A61L2400/18A61L2420/08A61L2430/02A61L2300/404A61L2300/102
Inventor 不公告发明人
Owner 北京科技大学天津学院
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