The invention discloses a preparation method of a homogeneous enhanced cellulose acetate hollow fiber membrane, and the preparation method comprises the following process steps: 1, preparation of a hollow braided tube reinforced body, to be more specific, using a 2D woven technology to prepare a cellulose acetate filament into a hollow braided tube with the diameter of 1-2mm, and using the hollow braided tube as the reinforced body; 2, preparation of a cellulose acetate membrane casting solution comprising 4-18% by mass of cellulose acetate, 2-20% by mass of a pore forming agent, 0-4% by mass of a non solvent and 58-94% by mass of a solvent; 3, preparation of the hollow fiber membrane, to be more specific, homogeneously coating the surface of the hollow braided tube with the membrane casting solution by use of a co-extrusion spinneret, then using a silk guide roller for leading to pass through the air gap of 2-20cm to immerse into a solidification bath at 10-50 DEG C for forming to obtain the hollow fiber membrane; the hollow fiber membrane has good mechanical properties and interfacial bonding state, is easy to process after being abandoned, and has the advantages of simple preparation method.