Crystalline powder of L-lysine L-glutamate

Abstract

The invention discloses crystalline powder of L-lysine L-glutamate and a preparation method of the crystalline powder of the L-lysine L-glutamate. The methanol content of the crystalline powder is less than 0.5wt%, the bulk density of the crystalline powder is more than 0.4g / ml, and the tapped density of the crystalline powder is more than 0.5g / ml. According to the preparation method, crystal obtained by crystallizing L-lysine L-glutamate methanol water is put into ethanol for converting, so that the problem that methanol is left over in a dilution crystallization process is effectively solved; compared with the existing products on the market, the prepared crystalline powder not only has good graininess, flowability and stability, but is also very low in amount of residual methanol.

Description

technical field [0001] The invention belongs to the technical field of crystallization, and in particular relates to a crystal powder of L-lysine L-glutamate and a preparation method thereof. Background technique [0002] L-lysine L-glutamate, English name L-Lysine L-glutamate, molecular formula C 11 h 23 N 3 o 6 , relative molecular mass 293.32. It is formed by complex crystallization of L-lysine and L-glutamic acid according to the mass ratio of 1:1. Its structure is as follows: [0003] [0004] L-Lysine L-Glutamate is white or white crystalline powder, odorless and has a unique taste. The melting point is 197°C. It is easily soluble in water, but hardly soluble in ethanol. Its aqueous solution is clear and colorless, with a pH value of 6.0-7.5. [0005] As an amino acid compound salt, L-lysine L-glutamate is different from amino acid derivatives. It has the biological effects of two amino acids at the same time, and even enhances the biological effects of each...

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Problems solved by technology

However, in the report on the dissolution and crystallization of L-lysine L-glutamate, there is either oil precipitation, or the product has high viscosity during the crystallization process, severe agglomeration, or easy to have solvent residues, which will seriously affect the product. the quality of

[0007] For example, in the patent CN102557974A, ethanol is used as anti-solvent for crystallization. By repeating the process, we found that the product agglomerates seriously during this process, and oil separation is easy to occur, resulting in subsequent separation difficulties and low product purity, which seriously affects the product. the quality of

[0008] For another example, in the patent US4415590, methanol is used as an antisolvent to carry out crystallization of L-lysine L-glutamate. Although the product particle size and stability are better, under the technique of using methanol as an antisolvent, the resulting L- In lysine L-glutamate crystalline powder, there will inevitably be the problem of methanol residue, and the residue is still high. In some products, the mass fraction of methanol residue is even greater than 3.2%, or even greater than 5%. Even more likely to 9%

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