Phosphorus binder based on iron hydroxide-peach gum, its preparation method and application
A technology of phosphorus binders and hydroxides, which can be used in applications, drug combinations, and medical preparations containing active ingredients, etc., and can solve the problems of side effects and low phosphorus adsorption capacity of patients
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[0112] A kind of preparation method of preferred phosphorus binding agent comprises the following steps:
[0113] (1) Dissolving: dissolve peach gum in water, then add dropwise an aqueous solution of iron salt, the solution temperature is 20-100°C, preferably 60-90°C, stir for 1 to 240 hours, preferably 1 to 5 hours;
[0114] (2) Add alkali: cool the reaction solution to 0-40°C, preferably room temperature, then dropwise add sodium hydroxide solution until the pH of the system reaches 6-13, preferably 7-10, and a large amount of precipitation occurs;
[0115] (3) Separation and purification: the precipitate is separated by centrifugation or filtration, washed with water or ethanol, dried and separated to obtain the final product.
[0116] The preparation method of another kind of preferred phosphorus binding agent comprises the following steps:
[0117] (1) Dissolving: Dissolving peach gum and weak base in distilled water, the solution temperature is 40-100°C;
[0118] (2) C...
Embodiment 1
[0151] experimental method:
[0152] Dissolve 10g of peach gum powder in 100mL of distilled water, stir at 70°C to fully dissolve, add 100ml of 20% by mass ferric chloride hexahydrate aqueous solution to the solution dropwise at 70°C, and continue stirring for 4 hour, then cool down to room temperature; dropwise add 20% mass ratio of NaOH aqueous solution, adjust the pH of the system to 8.0, a gel-like precipitate precipitates, centrifuges the precipitate, washes the precipitate 3 times with water, and the resulting product is dried, and the product is reddish-brown, a total of 4.8 g.
[0153] Experimental results:
[0154] After the product was ground and pulverized, the iron content was measured to be 17.14%, and the phosphorus absorption was 102.5 mg / g.
Embodiment 2
[0156] experimental method:
[0157] Dissolve 100g of peach gum powder and 25g of sodium citrate in 500mL of distilled water at a temperature of 90°C and stir to fully dissolve; add 20% by mass ferric chloride hexahydrate aqueous solution dropwise to the solution at a temperature of 90°C. At the same time, dropwise add 20% NaOH aqueous solution with a mass ratio to control the pH of the reaction solution to be 8.0-9.0, until there is obvious precipitation, stop the dropwise addition, and stir at 90°C for 5h to obtain a reddish-brown solution; after cooling to room temperature, centrifuge Remove the solid in the solution, add 4 times the volume of 95% ethanol to the supernatant, centrifuge after the precipitation is completely separated out, and wash the solid twice with 70% ethanol respectively; g.
[0158] Experimental results:
[0159] After the product was ground and pulverized, the iron content was measured to be 20.34%, and the phosphorus absorption was 158.3 mg / g.
PUM
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